Adverse Effects

Question 1

Jarisch-Herxheimer reaction

Answer 1

Natural penicillins

Question 2

interstitial nephritis and neutropenia

Answer 2

Nafcillin

Question 3

hepatitis

Answer 3

oxacillin

Question 4

Maculopapular rashes and Pseudomembranous colitis

Answer 4

ampicillin

Question 5

if used with tazobactam and vancomycin, produce greater incidence of acute kidney injury

Answer 5

piperacillin

Question 6

Hypothrombinemia or disulfiram-like reactions with ethanol

Answer 6

Cefotetan
Cefamandole
Cefoperazone

Question 7

most epileptogenic

Answer 7

imipenem

Question 8

Red man syndrome

Answer 8

Vancomycin

Question 9

neurotoxicity (tremors, seizures, psychosis)

Answer 9

cycloserine

Question 10

myopathy

Answer 10

daptomycin

Question 11

neurotoxicity, eosinophilia, fever, nephrotoxicity, rash, urticaria

Answer 11

Polymyxins (B&E)

Question 12

Most nephrotoxic

Answer 12

Neomycin
Gentamicin
Tobramycin

Question 13

Most ototoxic

Answer 13

Amikacin
Kanamycin

Question 14

Most vestibulotoxic

Answer 14

Streptomycin
Gentamicin
Tobramycin

Question 15

Auditory impairment

Answer 15

Neomycin
Amikacin
Kanamycin

Question 16

acute tubular necrosis

Answer 16

aminoglycosides

Question 17

produce skin reactions (aminoglycosides)

Answer 17

Neomycin
Streptomycin

Question 18

Teratogenic, nephrotoxic, photosensitivity, nephrotoxicity, reversible vestibulotoxicity

Answer 18

tetracyclines

Question 19

Gray baby syndrome

Answer 19

Chloramphenicol

Question 20

Aplastic anemia

Answer 20

Chloramphenicol

Question 21

oral or vaginal candidiasis due to alteration of normal microbial flora

Answer 21

chloramphenicol

Question 22

QTc prolongation; torsades de pointes arrhythmia

Answer 22

macrolides

Question 23

anorexia, acute cholestatic hepatitis

Answer 23

Erythromycin

Question 24

Hepatic dysfunction, pseudomembranous colitis

Answer 24

Clindamycin

Question 25

pain at infusion site and arthralgia-myalgia syndrome

Answer 25

Quinupristin-dalfopristin

Question 26

Drug interactions due to inhibition of CYP3A4 what drugs?

Answer 26

Quinupristin-dalfopristin warfarin, diazepam, quetiapine, simvastatin, cyclosporine

Question 27

serotonin syndrome

Answer 27

Linezolid

Question 28

lactic acidosis

Answer 28

Linezolid

Question 29

congenital malformations

Answer 29

Lefamulin

Question 30

rare fulminant hepatic failure

Answer 30

telithromycin

Question 31

acute hemolysis in G6PD deficiency

Answer 31

TMP-SMX Silver sulfadiazine mafenide acetate sulfonamides

Question 32

kernicterus

Answer 32

TMP-SMX Silver sulfadiazine mafenide acetate sulfonamides

Question 33

Stevens-Johnson syndrome

Answer 33

sulfonamides

Question 34

when given, patient with AIDS & pneumocystis pneumonia have high frequency of untoward rxn

Answer 34

TMP-SMX

Question 35

Photosensitive Fluoroquinolones

Answer 35

LPS Lomefloxacin Pefloxacin Sparfloxacin

Question 36

QTc prolongation (quinolones)

Answer 36

3rd & 4th Gen Quinolones

Question 37

may damage growing cartilage and cause arthropathy

Answer 37

quinolones

Question 38

temporary to permanent peripheral neuropathy

Answer 38

quinolones

Question 39

drug induced lupus

Answer 39

Isoniazid

Question 40

Ataxia seizures

Answer 40

Isoniazid

Question 41

Peripheral neuropathy due to pyridoxine deficiency

Answer 41

Isoniazid

Question 42

CYP450 inducer (increases elimination of other drugs)

Answer 42

Rifampin

Question 43

red orange urine, sweat and tears

Answer 43

Rifampin

Question 44

influenza like syndrome

Answer 44

rifampin

Question 45

retrobulbular neuritis resulting to loss of visual acuity and red-green color blindness

Answer 45

Ethambutol

Question 46

hepatotoxicity and optic neuritis

Answer 46

Rifabutin

Question 47

hyperamylasemia

Answer 47

pretomanid

Question 48

depression and psychoses

Answer 48

Cycloserine

Question 49

hepatosplenomegaly

Answer 49

Aminosalicylic acid

Question 50

peptic ulceration

Answer 50

Aminosalicylic acid

Question 51

reserved for px. who do not have preferable treatment options

Answer 51

bedaquiline

Question 52

should not be used to treat active tb in HIV patients

Answer 52

rifapentine

Question 53

hemolysis in patients with G6PD deficiency

Answer 53

Dapsone

Question 54

Pruritus

Answer 54

Dapsone

Question 55

skin discoloration and discoloration of the conjunctive

Answer 55

Clofazimine