Affective disorder drugs

Question 1

TCA

Answer 1

First generation antidepressants. End in Pramine and Tyline.

Significant first pass effect, lipid soluble and binds to proteins with slow elimination

Question 2

Imipramine

Answer 2

TCA for enuresis (bed wetting)

Metabolism–>desipramine which makes it have less antimuscarinic activity

Question 3

Amitriptyline

Answer 3

TCA also for chronic pain

Metabolism–>nortriptyline which makes it have less antimuscarinic activity

Question 4

Clomipramine

Answer 4

Also for OCD

Question 5

TCA MOA

Answer 5

Inhibit reuptake of biological amines (NE 5HT)
Block muscarinic cholinergic receptors
Block alpha1 adrenergic receptors- ORTHOSTATIC HYPOTENSION #1 limiting factor

Question 6

Antidepressants BBW

Answer 6

Increased risk of suicide

Question 7

Second Generation Antidepressants

Answer 7

Mirtazapine, Trazodone, buproprion

Question 8

Mirtazapine

Answer 8

Blocks 5HT2 and Alpha2 adrenergic receptors

Very sedating and associated with weight gain

Question 9

Trazodone

Answer 9

Inhibit serotonin reuptate, block 5HT2 receptors. Priapism side effect.

Question 10

Bupropion

Answer 10

Weak NE, 5HT, Dopa reuptake inhibitor. Can also be used for smoking cessation. Do not give to those with seizures or eating disorders.

Question 11

SSRI

Answer 11

Fluoxetine, paroxetine, fluvoxamine, sertaline, citalopram, escitalopram, vilazodone, and vortioexetine

Question 12

SSRI side effects

Answer 12

Sexual and GI dysfunction. Caution with MAO drugs due to Serotonin syndrome

Question 13

SNRI

Answer 13

Duloxetine, Ventaxine (NE at higher dose)

Question 14

Non selective MAO

Answer 14

isocarboxazid, phenelzine, tranylcypromine

Question 15

Mood stabilizers

Answer 15

Carbamazepine, valproate, lamotrigine, lithium

Can produce leucocytosis

Excreted through renal

Question 16

Lithium and its side effects

Answer 16

LMNOP
Movement (tremor)
Nephrogenic Diabetes insipidus (Block ADH cAMP production)
hypOthyroidism
Pregnancy problems