CNS Depressant drugs

Question 1

Barbiturates MOA

Answer 1

Bind to GABA receptor and increase Cl influx

No reversal agents

Question 2

Methohexital

Answer 2

Short half life, used to induce anesthesia

Question 3

Secobarbitol and pento barbitol

Answer 3

Intermediate half life for anxiety and insomnia

Question 4

Phenobarbitol

Answer 4

Good for some epilepsy

Question 5

Barbiturates contraindications

Answer 5

Do not give if Pt has porphyria

Question 6

Barbiturates caution

Answer 6

Induces hepatic enzymes and can screw up other drugs: Example–> birth control and coumadin

Question 7

ETOH metabolism

Answer 7

Via ADH into acetyl aldehyde which then gets broken down into acetate, both via zero order kinetics.

Also via micro 450 which is 1st order kinetics into Acetyl Ald.

Question 8

ETOH MOA

Answer 8

Enhances GABA affinity and also inhibits NMDA mediated glutamatergic neurotransmission

Question 9

ETOH tx

Answer 9

Disulfiram inhibits ADH causing acetyladehyde to build up causing severe headache, nausea, vomiting.

Metronidazole is disulfiram like.

Question 10

Methanol metabolism

Answer 10

–>Formaldehyde–>formic acid (Acidosis)

Use bicarb for acidosis and ETOH to saturate ADH to prevent metabolism of methanol