Affective Disorders Flashcards

(64 cards)

1
Q

What are mood disorders?

A

Disorders of mental status and function where altered mood is the/a core feature
A term referring to states of depression and of elevated mood
Used interchangeable with affective disorders

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Mood disorders are the commonest group of mental disorders, true or false?

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

How can disordered mood present?

A

As a primary problem or as a consequence of another disorder or illness e.g. cancer, dementia, drug misuse

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are mood disorders often associated with?

A

Anxiety symptoms and anxiety disorders

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What can depression be thought of as?

A

A symptom, syndrome and recurrent illness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Features of depression as a symptom

A

An emotion within the range of normal experience
Describes a state of feeling or mood that can range from near-normal experience to severe life-threatening illness
Systemic symptom with similarities to fatigue and pain
Typically considered as a form of sadness, not just an absence of happiness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Features of depression as a syndrome

A

Constellation of symptoms and signs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Features of depression as a recurrent illness

A

Recurrent depressive disorder

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

When does depression become abnormal?

A
No clear/convenient division
Consensus is problematic, often a matter of perspective 
Psychiatry places emphasis on; 
- persistence of symptoms 
- pervasiveness of symptoms 
- degree of impairment 
- presence of specific symptoms or signs
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What spheres do symptoms of depressive illnesses occur in?

A

Psychological
Physical
Social

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Psychological sphere of depression

A

Change in mood

  • depression
  • anxiety, inability to relax
  • perplexity, particularly in Puerperal illness
  • anhedonia

Change in thought content

  • guilt
  • hopelessness
  • worthlessness
  • any neurotic symptomatology e.g. hypochondriasis, agoraphobia, obsessions and compulsions, panic attacks
  • ideas of reference
  • delusions and hallucinations (if severe)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Physical sphere of depression

A

Change in bodily function

  • energy, fatigue most common
  • sleep, commonly insomnia with early wakening, disturbed sleep and difficulty falling asleep
  • appetite, more commonly reduced with weight loss
  • libido
  • constipation
  • pain

Changes in psychomotor functioning

  • agitation
  • retardation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Social sphere of depression

A
Loss of interests 
Irritability 
Apathy 
Withdrawal, loss of confidence, indecisive 
Loss of concentration
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is agitation?

A

State of restless over-activity, aimless or ineffective

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is anhedonia?

A

Loss of ability to derive pleasure form experience

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is apathy?

A

Loss of interest in own surroundings

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is anxiety?

A

Unpleasant emotion in which thoughts of apprehension and fear predominate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What is depression?

A

Unpleasant emotion in which sadness or unhappiness predominate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What is retardation?

A

Slowing of motor responses, including speech

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What is stupor

A

State of extreme retardation in which consciousness is intact
The patient stops moving, speaking, eating and drinking
On recovery, can describe clearly events which occurred while stuporose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

ICD 10 classification of depression

A

Symptoms must last for at least 2 weeks
No hypomanic or manic episodes in lifetime
Not attributable to psychoactive substance use or organic mental disorder
If psychotic symptoms or stupor then diagnosis is severe depression with psychotic symptoms - need to exclude other psychotic illnesses first before reaching this diagnosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Features of somatic syndrome

A

Marked loss of interest or pleasure in activities that are normally pleasurable
Lack of emotional reactions to events or activities that normally produce an emotional response
Waking 2 hours before normal time
Depression worse in the morning
Objective evidence of psychomotor agitation or retardation
Marked loss of appetite
Weight loss (5% body weight in a month)
Marked loss of libido

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

ICD 10 core symptoms of depression

A

Depressed mood that is abnormal for most of the day almost every day for the past two weeks, largely uninfluenced by circumstances
Loss of interest or pleasure
Decreased energy or increased fatiguability

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

ICD 10 additional symptoms of depression

A

Loss of confidence or self-esteem
Unreasonable feelings of guilt or self-reproach or excessive guilt
Recurrent thoughts of death by suicide or any suicidal behaviour
Decreased concentration
Sleep disturbance of any sort
Change in appetite

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
How many ICD 10 core symptoms and how many additional symptoms are needed to diagnose mild, moderate and severe depression?
At least 2 core symptoms and at least 2 additional symptoms for mild depression At least 2 core symptoms and at least 4 additional symptoms for moderate depression All core symptoms and at least 5 additional symptoms for severe depression
26
When is the risk of post-natal depression?
Increased risk of psychiatric admission in the 30 days following childbirth, risk for 24 months
27
What percentage of women experience baby blues within 2 weeks of childbirth?
75%
28
What percentage of women develop MDD within 3-6 months of childbirth?
10%
29
What is the incidence and risk of recurrence or puerperal psychosis?
1 in 500 deliveries | Risk of recurrence of 1-3 x with subsequent deliveries
30
Differential diagnoses for depression
``` Normal reaction to life event SAD Dysthymia Cyclothymia Bipolar affective disorder Stroke, tumour, dementia Hypothyroidism, Addison's, hyperparathyroidism Infections e.g. flu, infectious mononucleosis, hepatitis, AIDS/HIV Drugs ```
31
Treatment options for depression
Antidepressants Psychological treatments Physical treatments
32
Antidepressant types for use in depression
Selective serotonin reuptake inhibitors (SSRIs) Tricyclic antidepressants (TCAs) Monoamine oxidase inhibitors (MAOIs) Others
33
Psychological treatments for depression
Cognitive behavioural therapy IPT Individual dynamic psychotherapy Family therapy
34
Physical treatments for depression
ECT Psychosurgery DBS VNS
35
Measurement tools for depression
``` SCID SCAN HDRS BDI-II HADS PHQ-9 ```
36
What is mania?
A term to describe a state of feeling or mood that can range from near-normal experience to severe life-threatening illness Often associated with grandiose ideas, disinhibition, loss of judgement, with similarities to the mental effects of stimulant drugs
37
ICD 10 - categories of mania
``` Hypomania Mania without psychotic symptoms Mania with psychotic symptoms Other manic episodes Manic episode, unspecified ```
38
Features of hypomania
Lesser degree of mania with no psychosis Mild elevation of mood for several days on end Increased energy and activity, marked feeling of wellbeing Increased sociability, talkativeness, over-familiarity, increased sexual energy, decreased need for sleep May be irritable Concentration reduced, new interests, mild over-spending Differentiated from more severe mania as symptoms are not to the extent of severe disruption of work or social rejection
39
Features of mania (with or without psychosis)
1 week, severe enough to disrupt ordinary work and social activities more or less completely Elevated mood, increased energy, over-activity, pressure of speech, decreased need for sleep Disinhibition Grandiosity Alteration of sense Extravagant spending Can be irritable rather than elated
40
Differential diagnoses for mania
Psychiatric - mixed affective state - schizoaffective disorder - schizophrenia - cyclothymia - ADHA - drugs and alcohol Medical - stroke - MS - tumour - epilepsy - AIDS - neurosyphilis - Endocrine e.g. Cushing's, SLE, hyperthyroidism
41
Measurement tools for mania
SCID SCAN Young mania rating scale
42
Treatment options for mania
Antipsychotics - olanzapine - risperidone - quetiapine Mood stabilisers - sodium valproate - lamotrigin - carbamazepine Other treatment - lithium - ECT
43
What is bipolar disorder?
Bipolar disorder consists of repeated (2+) episodes of depression and mania or hypomania If there is no mania/hypomania then diagnosis is recurrent depression If no depression then diagnosis is hypomania or bipolar disorder
44
What is the lifetime prevalence rate of bipolar disorder?
0.7-1.6 n per 100
45
What is the point prevalence rate of mania?
0.08-0.8
46
What is the mean age of onset of bipolar disorder?
21
47
What is early onset bipolar disorder?
Onset 15-19 years, usually positive FH
48
What is the lifetime prevalence rate of depression?
2.9-12 n per 100
49
What is the point prevalence rate of depression?
3.7-7.7
50
What sex is more affected by depression?
Females 2 : 1 males
51
What is the mean age of onset of depression?
27 | Range 18-44 for highest risk
52
In what people is MDD less common?
Employed | Financially dependent
53
What is the onset of depression associated with?
Adverse life events
54
How long does the typical episode of major depression last?
4-6 months
55
What percentage of people with major depression will recover by 26 weeks?
54%
56
What percentage of people with major depression fail to recover?
12%
57
What percentage of people with major depression have further episodes?
80+%
58
What percentage of people with major depression die by suicide?
15%
59
How long does the typical manic episode last?
1-3 months
60
What percentage of people with bipolar disorder will recover by 10 weeks?
60%
61
What percentage of people with bipolar disorder/mania fail to recover?
5%
62
What percentage of people with bipolar disorder/mania have further episodes?
90%
63
What number of people with bipolar disorder/mania have a poor outcome and good outcome?
1/3 poor outcome | 1/3-1/4 good outcome
64
What percentage of people with bipolar disorder/mania die by suicide?
10%