Agents For Select GI Infections Flashcards
What is the general treatment for H pylori?
Combination therapy of at least 2 antibiotics + PPI
What is the triple therapy for H pylori?
14 day treatment
Only for low clarithromycin resistance areas (<15%) and no prior exposure to clarithromycin
-PPI
-Clarithromycin
-Amoxicillin or Metronidazole (if anaphylactic allergy to amoxicillin)
What is quadruple therapy for H pylori?
PPI twice daily dosing, other agents 4x daily
-PPI (prazole)
Metronidazole
-Amoxicillin (tetracycline for PCN allergy)
-Bismuth subsalicylate (can substitute clarithromycin for bismuth; can substitute levofloxacin for failed eradication)
What should be considered for complete healing of ulcers due to H pylori?
Consider PPI continuation therapy for several weeks after 10-14 day H pylori combination therapy
Which antibiotics are used to treat C diff?
Oral vancomycin only IV metronidazole (for severe disease + oral vancomycin)
Which abx should be used to treat campylobacter jejuni?
Azithromycin
Which abx should be used to treat salmonella?
Cirpoflaxacin/Levofloxacin
Which abx should be used to treat shigella?
Ciprofloxacin/Levofloxacin
What are the anithelmintic agents?
Benzimidazoles(albendazole and mebendazole)
Miscellaneous
What are the miscellaneous antihelmintics?
Ivermectin, nitazoxanide, praziquantel, pyrantel pamoate
What are the anti-protozoals for GI infections?
Paromomycin
Metronidazole and tinidazole
What is the treatment of choice for entamoeba histolytica?
Metronidazole followed by paromomycin
What is the treatment of choice for ancylostoma species and necator americanus?
Albendazole
What is the treatment of choice for ascaris lumbricoides?
Albendazole
What is used to treat giardiasis infection?
Metronidazole
