Immunologic Mechanisms of IBD pt.2 Flashcards
What are the characteristics of Crohn’s disease?
What are the characteristis of ulcerative colitis?
What are the environmental factors influencing IBD?
Describe the spatial organization of microbial communities in the GI tract
The human gut may hold approx 10^14 cells, 10 fold greater than the rest of the human body
This organismal diversity carries great genetic diversity
What is the dysbiosis that occurs in both UC and CD?
What are the effects of a high fiber, high fat, high protein and high carb diet on the gut microbiota?
How does CARD15/NOD2 work?
Describe how defective function of marophages is a possible mechanism for Crohn’s disease associated with NOD2 mutations
Leads to persisent intracellular infection of macrophages and chronic stimulation of T cells by macrophage-infecting organisms
Describe how defective epithelial cell responses are a possible mechanism of Crohn’s disease caused by NOD2 mutations
Leads to loss of barrier function and increasd exposure to the mucosal microflora
Describe how defective conditioning of APCs is a possible mechanism of Crohn’s disease caused by NOD2 mutations
Leads to inappropriate activation of APCs and disruption of the homeostatic balance of effector and regulatory cells
Describe the homeostasis of the gut
Describe SCFAs and induction of Treg cells
Describe the role of segmented filamentour bacteira (SFB), bacteroides fragilis, and clostridium spp on the immune processes in the gut
Describe microbial effects on the host
Describe the mucosal firewall
Explain the dysbiosis in the gut that occurs with IBD
Explain the major phases associated with development of IBD
Describe T cell activation and differentiation
Describe the role of cytokines in IBD
All about SNPs not mutations in cytokine genes!
Describe Treg and Th17 cells in IBD
