Aging Changes In The AC/vitreous/lacrimal System Flashcards

1
Q

An acute rise in EVP results in a _____ ratio of increase IOP

A

1:1

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2
Q

Conventional pathway

A
  • Cornrealscleral outflow
  • TM and SC (main structures)
  • IOP dependent
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3
Q

Unconventional pathway

A
  • uveoscleral outflow
  • ciliary muscle bundle
  • IOP independent
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4
Q

Factors affecting IOP

A

Peak int he morning
Corneal thickness
Steroid

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5
Q

Outflow obstruction

A

Occlusive angle
-diabetes, uveitis, hyphema, pseudoexfoliation glaucoma, pigment dispersion glaucoma

Injury to the TM
-Fuchs heterochromic iritis, glaucomatocyclitic crisis

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6
Q

Classic Goldman equation

A

An acute ride in EVP results in a 1:1 ratio of increase in IOP

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7
Q

Aging changes in anterior chamber

A
  • reduced anterior chamber depth, cortical cataract has more effect on this change
  • reduced uveoscleral outflow. Increase in amount of connective tissue in ciliary muscle
  • accumulation of extracellualr matrix plaque in TM
  • increased outflow resistance in the TM and SC
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8
Q

Vitreous function

A

Support
Diffuse barrier
Metabolic barrier
Transparency

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9
Q

Vitreous function: support

A

PVD; macular edema

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10
Q

Vitreous function: metabolic buffer

A

Reduce neovascularixation in retina

  • neovascular glaucoma
  • NSC
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11
Q

Vitreous function: transparency

A
  • synchisis scintillations

- asteroid hyalosis

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12
Q

Aging change of the vitreous

A

The gel structure becomes more liquefied with aging

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13
Q

Breakdown of the vitreous gel and aggregation of collagen fibrils due to increase of liquid potion

A

Vitreous syneresis

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14
Q

What is the most common cause of pVD

A

Vitreous syneresis

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15
Q

Floaters

A

Aggregation of collagen fibrils

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16
Q

Where is the change of the gel of the vitreous most likely to happen with age

A

In the center

17
Q

Mucus layer composition

A

Mucin

18
Q

Mucus layer functions

A
  • provides medium for aqueous
  • cover epithelium
  • trap debris and bacteria
19
Q

Mucus layer sources

A
  • goblet cells (primary)

- squamous cells of cornea and conj

20
Q

Lipid layer composition

A

Meibomian oil

21
Q

Functionsof lipid layer

A

Slow the evaporation of the awe opus layer

22
Q

Vitreous compositions

A
Water 
Collagen
HA
Vitreal cells 
Vitamin C
23
Q

Functions of lipid layer

A

Slow the evaporation of the aqueous layer

24
Q

Sources of the lipid layer

A
  • meibomian gland (primary)

- Zeiss and Moll

25
Q

Composition of aqueous layer

A
  • water
  • electrolytes
  • Na and CL (osmolarity)
  • K and Ca (cornea epeothelium health)
  • proteins
26
Q

Functions of the aqueous layer

A
  • provide protection
  • buffering
  • regulation cornea epithelium proliferation’s
27
Q

Sources of the aqueous layer

A

Main lacrimal gland

Accessory lacrimal gland

28
Q

Clinical evaluation for tear secretion

A

Schirmer 1
Schirmer II
Phenol red thread test
Meinscometry

29
Q

Clinical evaluation of tear film stability

A

TBUT
Ocular protection index
Videokeratography
Tear turnover

30
Q

Clinical evaluation of the tear film osmolarity

A

Tear film osmolarity
Tear ferining
Tear evaporation

31
Q

Clinical evaluation of the lipid layer

A

Inferometry

Meibomtery

32
Q

Ocular surface clinical evaluation

A

Fluorescein
Rosa bengal
Lissamine green

33
Q

Aginging changes of the lacrimal systems

A
  • goblet cell population may decrease
  • reduced in tear reflex secretion
  • change in composition of the meibomian secretion
  • increase of plugged meibomian gland pores
  • reduced lacrimal drainage capacity
34
Q

Major components of the aqueous layer

A

Water

35
Q

What are the main contributor fir the osmolarity of the aqueous layer

A

Na And CL

36
Q

What are the K and Ca responsible for in the aqueous layer

A

Corneal epithelium health

37
Q

Which outflow system is reduced with age

A

Unconventional

38
Q

What helps the mucus layer stay stable on the corneal epithelium

A

Glycocalyx