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Flashcards in AIDS Deck (20):
1

Compound workingas an immunosuppressive signaling molecule

Adenosine

2

ADA deficiency

Can't deaminate adenosine to inosine; immunosupression, bubble boy

3

Lack of IFN-gamma receptor

Causes immunodeficiency due to inability to active NK cells in an innate immune response or T-cells in a adaptive one

4

HIV virus class

Lentivirus, retrovirus

5

HIV-1

Global distribution, more virulent. Passed down from chimpanzees to humans at least three times

6

HIV-2

Less virulent than 1, found in W. Africa and India. Originated in the Sooty Mangabey

7

Unique feature of HIV as a retrovirus

Can infect non-dividing cells.

8

Exogenous vs. endogenous retroviruses

Recent emigrants vs. ancient proviruses.

9

gag

Core proteins and matrix proteins

10

pol

RT, protease and integrase

11

Binding of virion to cell

Binds to CD4 and coreceptor

12

Antigenic variation

Due to error prone transcription of RNA-pol.

13

Coreceptors

CXCR4 on T-cells or CCR5 on monocytes, macrophages.

14

Infection from mucosal surface

Intraepithelial dendritic cells bind HIV with DC-SIGN. Virus is internalized and dendritic cells migrate to lymph nodes.

15

AIDS

Decline in CD4 T cell results in an inability to mount an effective immune response

16

Used by host to control infection

Neutralizing antibodies and CD8 T cells.

17

Ability to resist anti-viral drugs

Due to high mutation rate

18

HAART

Highly ative antoretroviral therapy. Combination therapy with protease inhibitors, nucleoside analogs.

19

Elite neutralizers

Patients that make antibodies that effectively neutralizes HIV. Bind to one of four epitopes on gp120

20

gp120

Binds CD4