Alcoholic-related liver disease Flashcards Preview

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Flashcards in Alcoholic-related liver disease Deck (13):
1

What organ absorbs majority alcohol and passes it to liver

Stomach

2

What is the product of alcohol metabolism

Acetaldehyde

3

What are the three metabolic pathways for alcohol

CYP2E1, ADH and catalase

4

What does an increase in NADH cause in terms of fatty acids

An increase in fatty acid synthesis

5

What does a decrease in NAD+ do in terms of fatty acids

Decreases fatty acid oxidation

6

What immune cell destroys hepatocytes when an aldehyde adduct is formed

Neutrophils

7

What is an aldehyde adduct

A product when acetaldehyde binds to an own body molecule

8

Symptoms

Hepatomegaly, pain, jaundice, ascites (cirrhosis symptoms

9

What are mallory bodies

Damaged intermediate filaments in the cytoplasm due to alcoholic hepatits

10

Normal blood test changes

Increased neutrophils, decreased platelets and decreased blood sugar

11

LFTs

Super increased AST, inc. ALT, ALP and GGT

12

Diagnosis

US and blood test

13

Treatment

No alcohol, corticosteroids and cirrhosis treatment if necessary