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Flashcards in Non alcoholic fatty liver disease Deck (15):
1

Describe the spectrum of disease from least to most severe

Steatosis, steatohepatitis, fibrosis and cirrhosis

2

What is a brief description of NAFLD

Fat deposits in the liver, not caused by alcohol or a viral infection, that causes liver disease

3

What syndrome does NAFLD usually derive from

Metabolic syndrome

4

What is the criteria for metabolic syndrome

3/5 of the following. Obesity, hypertension, diabetes, hypertriglyceridaemia and hyperlipidaemia

5

NAFLD occurs in 3/5 obese people. True or false

False it is 3/4 of obese people

6

Describe steatosis

Decreased secretion of fatty acids into the blood and increased uptake and synthesis of fatty acids from the blood

7

What is happens to the nucleus of cells in steatosis

Nucleus is pushed to the side of the cell

8

What is thought to be linked to steatosis

Insulin resistance

9

What is the appearance of the liver in steatosis

Large, soft, yellow and greasy

10

Steatosis and inflammation=what???

Steatohepatitis

11

How does steatohepatitis cause fibrosis

Causes stellate cells to lay down fibrotic tissue and this causes fibrosis

12

Symptoms

Once significant damage occurs (fibrosis/cirrhosis); hepatomegaly, pain, jaundice and accumulation of ascites

13

What is effect of the LFTs in NAFLD compared to AFLD

Increase in ALTs and smaller increase in ASTs. In AFLD ASTs have a large increase and the AST:ALT ratio is over 2.

14

How to diagnose

US/CT/MRI. Biopsy of liver that shows over 5% of fat is abnormal

15

Treatment

Fibrosis and cirrhosis are irreversible but normal cirrhosis treatment. Adopt a healthy lifestyle and possibly medication for blood glucose levels to prevent worsening of insulin resistance