Alcoholism

Question 1

DSM V criteria for alcohol use disorder:

mild-

moderate-

severe-

Answer 1

mild- 2-3 symptoms

moderate- 4-5 symptoms

severe- 6 or more symptoms

Question 2

Why do women get the short end of the stick when it comes to alcohol?

Answer 2

• BAC higher due to smaller body size, lower levels of gastric Alcohol DH and higher proportion of fat
• greater incidence of hepatic disease
• greater cerebral atrophy
• progresses more rapidly

Question 3

does evidence show that rates of alcoholism are substantially higher in relatives of alcoholics than in relatives of non-alcoholics

Answer 3

yassss

Question 4

children of alcoholics have no increase risk

Answer 4

false, 3 to 4 fold increased risk for developing an alcohol use disorder

Question 5

concordance rate of alcoholism between monozygotic and dizygotic twins

Answer 5

mono: 60%
diz: 39%

Question 6

adoption shows no difference if babies were raised by non-alcoholic or alcoholic parents

Answer 6

true; it seems to be a nature vs nurture situation

Question 7

indirect tests for alcohol biomarkers

Answer 7

measure of long term drinking

Question 8

direct test for alcohol biomarker

Answer 8

immediate detection of drinking

Question 9

SASQ

Answer 9

single alcohol screening Question- when was the lasat time you had more than 5 drinks in one day

Question 10

CAGE

Answer 10

Cut Down
Annoyed
Guilty
Eye Opener

Question 11

Audit-C

Answer 11

• How often
• how many
• more than 6 drink on one occasion?

Question 12

Evidence-based simple intervention used to identify and reduce, and prevent problematic use, abuse and dependence on alcohol

Answer 12

SBIRT- screening, brief intervention and referral to treatment

Question 13

stages of change

Answer 13

1. pre-contemplation
2. contemplation
3. preparation
4. preparation
5. action
6. maintenance

Question 14

treatment intervention

Answer 14

1. feedback
2. psychotherapy to deal with ambivalence
3. menu of treatment options
4. let patient choose
5. relapse prevention

Question 15

chronic alcohol use: alcohol is an agonist at the

Answer 15

GABA receptor leading to depressant effect

Question 16

alcohol is an antagonist at the

Answer 16

NMDA receptor inhibiting excitatory neurotransmission

Question 17

alcohol releases _____ and _____

Answer 17

dopamine and endorphines; they lead to a positive brain reinforcement effect

Question 18

effects of alcohol withdrawal

Answer 18

• CNS hyperactivity

Question 19

CIWA

Answer 19

managing alcohol withdrawal:

1. nausea/vomiting
2. tremor
3. paroxysmal sweats
4. anxiety
5. tactile disturbances
6. auditory disturbances
7. visual disturbances
8. headache
9. agitation
10. disorientation, clouding of sensorium

Question 20

hallmarks of complicated withdrawal

Answer 20

1. elevated vital signs
2. hallucinosis
3. seizure
4. delirium tremens- life threatening

Question 21

possible tx. for alcohol withdrawal

Answer 21

benzodiazepines— act at the GABA receptor

Question 22

• disulfram
• acamprosate
• naltrexone
• topiramate
• ondansetron

Answer 22

long term management of alcoholism

Question 23

most effective pharmacotherapy option

Answer 23

naltrexone: MU- opioid receptor antagonist

Question 24

acamprosate

Answer 24

alters GABA and NMDA systems

Question 25

Disulfiram

Answer 25

• inhibition of ethanol metabolism

Question 26

interactive tx.

Answer 26

• peer support groups

- psychotherapies