opioids Flashcards
1
Q
opioid agonists bind to
A
mu opioid receptors
2
Q
opioid receptors are distributed in the
A
CNS and gut
3
Q
Factors contributing to Drug of choice
A
- availability
- cost
- rapidity of onset
- efficacy
4
Q
has opioid overdose been decreasing
A
yea
5
Q
Opioid agonist popular today
A
fentanyl
- more potent than morphine
6
Q
can fentanyl cross the brain blood barrier?
A
yea, very lipophilic
7
Q
infection drug use medical co-morbidities
A
local and systemic
8
Q
methadone has a long or short half life?
A
long half life
9
Q
COWs
A
clinical opiate withdrawal scale
- clinical observations and self-reported symptoms
10
Q
clonidine
A
helps with anxiety, sweating, tachy and insomnia
- alpha-2-adrenergic agonist
11
Q
methadone
A
can be used in the management of relapse prevention due to its mimicry of opioid receptor agonist
12
Q
Can buprenorphine also be used in relapse prevention?
A
yea
13
Q
naltrexone works by
A
blocking of drug targets by receptor antagonist MOA
