ALL

Question 1

What differentiates between ALL and LBL?

Answer 1

• % of BM lymphoblasts
  If <20%: LBL
  >20% : ALL

Question 2

Standard risk ALL (NCCN v1 2025)

Answer 2

”Happy Teems Enjoy Partying During Prom Season”

Question 3

“Happy Teens Enjoy Partying During Prom Season” - standard risk ALL (NCCN v1 2025)

Answer 3

🅗 H – Hyperdiploidy (51–65 chromosomes)
🅣 T – t(12;21) → ETV6::RUNX1
🅔 E – ETV6::RUNX1 (again, emphasize importance)
🅟 P – PAX5 P80R
🅓 D – DUX4 rearranged
🅟 P – PBX1::TCF3 [t(1;19)]
🅢 S – Standard BCR::ABL1 (Ph+) without IKZF1 deletion or prior CML
happy teens enjoy partying (5 ppl), order duxell4 & during prom season

Question 4

Poor risk ALL (NCCN v1 2025)

Answer 4

”The BAD NEWS ALL-Stars”

Question 5

”The BAD NEWS ALL-Stars” - poor risk ALL (NCCN v1 2025)

Answer 5

”The BAD NEWS ALL-Stars”
🌩️ B – BCR::ABL1 (Philadelphia Chromosome) + IKZF1/CML
🧨 A – Abnormal Ploidy (Hypodiploidy <44 chromosomes)
🕳️ D – Dismal Rearrangements: KMT2A (MLL) rearranged
😈 N – Near-Haploid/Low-Hypodiploid
🧬 E – ETV6::RUNX1-like (without the real fusion)
👹 W – iAMP21 (Intrachromosomal Amplification of Chromosome 21)
🧛 S – SH2B3, IKZF1 Deletions, CRLF2 rearranged (Ph-like ALL)