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Allen review slides Flashcards

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1
Q

an immune reaction against self. can be organ specific or widespread

A

Autoimmune Disease

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2
Q

Rheumatoid Arthritis, lupus, MS, Diabetes (pancreas), Graves Disease (thyroid) are examples of

A

Autoimmune diseases

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3
Q

the class of an antibody molecule is determined solely by its

A

heavy chain

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4
Q

antibodies have _____ numbers of large (heavy) and small (light) peptide chains

A

equal numbers

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5
Q

antibodies have _______ identical antigen binding sites

A

multiple

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6
Q

humanization of antibodies _______ immunogenicity

A

reduces

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7
Q

murine: % human and suffix

A

0% human, -omab

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8
Q

chimeric: % human and suffix

A

65% human, -ximab

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9
Q

humanized: % human and suffix

A

> 90% human, -zumab

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10
Q

fully human: % human and suffix

A

100% human, -umab

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11
Q

new capillary blood vessel growth in the body. natural process for healing and reproduction

A

angiogenesis

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12
Q

what is angiogenesis

A

new capillary blood vessel growth in the body

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13
Q

humanized antibody used in caner. targets programmed cell death receptor 1

A

pembrolizumab (Keytruda)

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14
Q

target of pembrolizumab (Keytruda)

A

programmed cell death receptor 1

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15
Q

autologous cellular immunotherapy designed to induce immune response against PAP (antigen in prostate cancers)

A

sipuleucel-T (Provenge)

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16
Q

target of sipuleucel-T (Provenge)

A

PAP (antigen in prostate cancers)

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17
Q

humanized monoclonal antibody that binds to HER2 gene and prevents dimerization and induces apoptosis through ADCC

A

Herceptin

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18
Q

target of Herceptin

A

HER2

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19
Q

recombinant chimeric mAb used in head and neck and colorectal cancer. prevents dimerization of EGFR

A

cetuximab (Erbitux)

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20
Q

target of cetuximab (Erbitux)

A

EGFR

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21
Q

Regorafenib inhibits ______

A

angiogenesis

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22
Q

what drug inhibits angiogenesis

A

Regorafenib (Stivarga)

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23
Q

anti-IL5 therapy used for asthma

24
Q

what are anti-IL5 therapies used for

25
difference in infliximab and adalimumab
infliximab=chimeric, adalimumab=human
26
is infliximab or adalimumab chimeric
infliximab
27
mAb are currently used to reduce __________ associated with __________ __________
inflammation, Rheumatoid arthritis
28
are men or women more likely to develop RA
women
29
undesirable immune reaction produced by normal immune system. immune response is exaggerated
hypersensitivity
30
how many types of hypersensitivity reactions are there
4
31
antibody mediated hypersensitivities
type 1, 2, 3
32
cell mediated hypersensitivity
type 4
33
are T or B cells responsible for CELL-mediated immunity
T-cells
34
are T or B cells responsible for producing antibodies
B cells
35
Classic Allergy
Type 1 Hypersensitivity
36
symptoms resulting from allergic responses are known as
anaphylaxis
37
what is used to diagnose allergies
skin test
38
is type 1 hypersensitivity immediate or delayed
immediate
39
examples of type1 hypersensitivity
hay fever, asthma, eczema, bee stings, food allergies
40
hay fever, asthma, eczema, bee stings, food allergies
type 1 hypersensitivity
41
IgG mediated-Cytotoxic Hypersensitivity
Type 2 hypersensitivity
42
utilizes antibodies that can destroy normal cells by lysis or ADCC
type 2 hypersensitivity
43
blood transfusion reaction
type 2 hypersensitivity
44
ex of type 2 hypersensitivity
blood transfusion reactions
45
immune complex mediated hypersensitivity/"Frustrated Phagocytes"
type 3 hypersensitivity
46
slight excess of antigen, antigen-Ab complex activated complement and stimulates neutrophil and basophil degranulation
type 3 hypersensitivtiy
47
is type 4 hypersensitivity delayed or immediate
delayed
48
ex of type 4 hypersensitivity
positive Tb test, poison ivy, Multiple sclerosis
49
positive Tb test, poison ivy, Multiple sclerosis
type 4 hypersensitivity
50
Th1 and Th17 act against myelin ---> demyelination in CNS
multiple sclerosis
51
IgE mediated hypersensitivity
type 1 hypersensitivity
52
administration of antiserum containing preformed antibodies. gives immediate protection against recent infection or ongoing disease
passive immunotherapy | artificial passive immunity
53
2 examples of antiserums that yield passive immmunity
rabies vaccine, snake antivenom
54
antibodies created within a different person or animal
antiserum
55
an immediate hypersensitive reaction develops in less than ___ hours
24 hours
56
a delayed hypersensitivity reaction develops in ____-____ hours
24-48 hours

Molecular Bio (3 decks)

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