Allergy Flashcards
(18 cards)
What immunoglobulin is involved in Type 1?
IgE (You are Ellergic)
T1 - what cell releases its mediators due to triggering of IgE receptors?
Mast cells
Why is type one rapid?
Because releases pre fprmed mediators eg histamine, chemokines and heparin
Examples of T1?
Eczema, ashtma, rhinitis (hayfever)
How can you define T2?
Antibody to cell bound antigen
What are typical examples of T2?
Drug allergies eg Penicillin
Describe T2
Antibodies are directed against antigens on the surface of cells or other tissue components
Normally either self antigens thus auto immune or drugs having entered a cell
What immunoglobulins are involved in T2?
IgG, IgM
Describe T3
reactions resulting from the depositionor formation of immune complexes in the tissues
What immunoglobulins are ivolved in T3?
G and M
Related diseases?
Acute post-streptococcal glomerulonephritis and SLE
Describe T4?
DELAYED, mediated by T lymphocytes which react with antigen and release interleukin-2, interferongamma and other Thl cytokines
Common antigens for type 4?
Metals
Associated disease for T4?
Dermatitis
True or false type 4 is cell mediated?
TRUEEEEE
Role of TH2?
innate inflam response
Drive for immunoglobulin production
Multiple cytokine release
Role of IgE?
Creates an immune response
What is in the atopic triad?
Rhinitis, Asthma, Eczema
