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PHA6124 LAB Manufacturing Pharmacy > AlMgOH Oral Suspension > Flashcards

AlMgOH Oral Suspension Flashcards

(48 cards)

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1
Q

disperse system in which INTERNAL phase is dispersed UNIFORMLY as FINELY DIVIDED INSOLUBLE particles throughout the external phase

A

suspension

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2
Q

consist of INSOLUBLE SOLID PARTICLES having the range from 0.5-5 microns which is maintained uniformly throughout the suspending vehicle

A

internal phase

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3
Q

generally AQUEOUS and in some instances, it may be an ORGANIC liquid or OILY liquid for non-oral use

A

external phase

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4
Q

suspension classification based on GENERAL CLASSES

A
  1. oral susp
  2. externally applied suspension
  3. parenteral susp
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5
Q

suspension classification based on PROPORTION OF SOLID PARTICLES

A
  1. diluted susp
  2. concentrated susp
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6
Q

suspension classification based on ELECTRO KINETIC NATURE of solid particles

A
  1. flocculated susp
  2. deflocculated susp
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7
Q

suspension classification based on SIZE OF SOLID PARTICLES

A
  1. colloidal susp
  2. coarse susp
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8
Q

what type of suspension?
2-10% w/v solid

A

diluted susp

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9
Q

what type of suspension?
50% w/v soli

A

concentrated susp

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10
Q

what type of suspension?
1-500 nm in diameter

A

colloidal susp

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11
Q

what type of suspension?
more than 500 nm in diameter

A

coarse susp

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12
Q

reasons for susp formulation

A
  1. sustaining effect
  2. stability
  3. taste
  4. basic solubility
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13
Q

When drug is ________________ in the ______________________, we opt to manufacture or produce pharmaceutical suspension

A

insoluble in the delivery vehicle

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14
Q

components of a suspension

A
  1. API
  2. wetting agent
  3. flocculating agents
  4. viscosity agents
  5. buffer
  6. preservative, colorant, flavorant
  7. water, glycerin, sorbitol
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15
Q

pharmacologic category of Aluminum Magnesium Hydroxide Suspension

A

antacid

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16
Q

Antacids _______________ gastric acidity resulting in an ____________ in the pH of the ______________ and in the ______________

A

reduce gastric acidity; increase pH of stomach and duodenum

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17
Q

neutralize excess gastric hydrochloric acid associated with gastritis and peptic ulcer

A

antacid

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18
Q

Most antacids raise the gastric pH to ____________

A

4-5

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19
Q

uses of antacid

A

for:
1. uncomfortable feeling from overeating
2. heartburn
3. dyspepsia (indigestion)
4. duodenal ulcer
5. other non-specific GI symptoms

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20
Q

Al(OH)3 and MgOH2 are ____________________ in nature

Study These Flashcards
A

basic (weak bases)

21
Q

Ideal antacid and soluble in acidic medium

22
Q

Al(OH)3 color

23
Q

Al(OH)3 is a viscous suspension or _____________

24
Q

pH range of Al(OH)3

Study These Flashcards
A

pH 5.5 – 8.0

25
Al(OH)3 may ____________ with the absorption of other drugs by __________ with them (e.g. tetracycline)
interfere; binding
26
Al(OH)3 can cause __________________
constipation
27
constipation is due to production of ___________, a water soluble astringent salt from Al(OH)3 and HCl
AlCl3
28
characteristics of MgOH2
white, fine odorless, amorphous powder
29
MgOH2 is ____________ in water and alcohol but _____________ in dilute acids
insoluble; soluble
30
used as laxatives in high doses
MgOH2
31
Advantages of MgOH2
1. fast onset of action 2. no systemic alkalosis 3. high acid neutralizing capacity
32
Disadvantages of MgOH2
1. short doa 2. laxative/diarrhea 3. hypermagnesia 4. CI to px with kidney disease
33
mL of water added upon addition of MgOH2 and sorbitol
100 mL
34
minutes of agitation before addition of Al(OH)3
5 minutes
35
CMC is placed in _________ after which 50 mL water is added
mortar
36
mL of water heated to 50 degrees before adding dissolved saccharin sodium and sodium benzoate
50 mL
37
role of sorbitol
wetting agent
38
role of carboxymethyl cellulose
suspending agentr
39
role of peppermint oil
flavorant
40
role of saccharin sodium
sweetening agent
41
role of sodium benzoate
preservative
42
role of purified water
solvent
43
Examples of flocculating agents
Calcium chloride, aluminum chloride
44
Examples of wetting agents
Sodium lauryl sulfate, benzalkonium chloride
45
Examples of viscosity agents or suspending agents/thickeners
Methyl cellulose, bentonite, tragacanth
46
Wetting agents are also known as
Surfactants
47
Added to DISPERSE SOLID PARTICLES in the EXTERNAL PHASE
Wetting agents or surfactants
48
Stabilize the suspension to a desired pH range
Buffer

PHA6124 LAB Manufacturing Pharmacy (3 decks)

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