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PHA6124 LAB Manufacturing Pharmacy > ORS Powder > Flashcards

ORS Powder Flashcards

1
Q

mixture of finely divided drugs and/ or chemicals in a dry form

A

powders

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2
Q

may be used to describe the PHYSICAL FORM of a material that is DRY SUBSTANCE composed of FINELY DIVIDED powders

A

powders

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3
Q

may use to describe a type of pharmaceutical

A

powders

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4
Q

intended for internal or external use

A

medicated powder

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5
Q

Powders are available in ______________ or ______________ form

A

crystalline or amorphous

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6
Q

Powders were found to be a _________________ mode of administering drugs derived from _________ origin

A

convenient; plant

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7
Q

Most active and inactive pharmaceutical ingredients occur in the solid state as _______________________ or ___________ of various morphologic structures

A

amorphous powders or crystals

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8
Q

a solid dosage form composed of a solid or mixture of solids reduced to
affinely divided state and intended for internal or external use

A

powders

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9
Q

classification of powders according to PARTICLE SIZE

A
  1. very coarse
  2. coarse
  3. moderately coarse
  4. fine
  5. very fine
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10
Q

classification of powders according to USE or manner of ADMINISTRATION

A
  1. internal
  2. external
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11
Q

classification of powders according to manner of DISPENSING

A
  1. bulk
  2. divided
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12
Q

particle size of pharmaceutical powders and granules may range from _________________ in diameter to extremely fine, approaching colloidal dimensions of 1 micrometer or less

A

10 mm or 1 cm

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13
Q

all particles pass through a #8 sieve and NMT 20% pass through a #60 sieve

A

very coarse

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14
Q

all particles pass through a #20 sieve and NMT 40% pass through a #60 sieve

A

coarse

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15
Q

all particles pass through a #40 sieve and NMT 40% pass through a #80 sieve

A

moderately coarse

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16
Q

all particles pass through a #60 sieve and NMT 40% pass through a #100 sieve

A

fine

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17
Q

all particles pass through a #80 sieve. There is no limit
to greater fineness

A

very fine

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18
Q

can be taken orally like ORS and administered through the nose as snaps or blown into a body cavity as insufflations

A

internal powders

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19
Q

dusting powders: medical or surgical

A

external powders

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20
Q

for superficial skin conditions in which shall not be used on open
wounds or broken skin

A

medical powders

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21
Q

sterile and used inside the body cavities

A

surgical powders

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22
Q

locally applied nontoxic preparations with no systemic effect

A

dusting powders (topical bulk powders)

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23
Q

applied as lubricant, protective, absorbent, antiseptic, antipruritic, astringent, antiperspirant

A

dusting powders (topical bulk powders)

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24
Q

used to clean teeth and polish teeth

A

dentrifices

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25
Q

dissolved in water and used as
antiseptic or cleansing agent of the body cavity

A

douche powders

26
Q

also known as undivided powders

A

bulk powders

27
Q

dusting powders, effervescent antacids, laxatives, dietary nutrients,
and supplements

A

bulk powders

28
Q

examples are drug packets, sachet, capsules

A

divided powders

29
Q

usually folded in paper dispensed in metal foil, small sealed or reusable plastic valve or container

A

divided powders

30
Q

requirements in powder manuf

A
  1. homogenous blending
  2. reduction into a more advantageous particle size
31
Q

blending techniques

A
  1. spatulation
  2. trituration
  3. geometric dilution
  4. sifting method
  5. tumbling
32
Q

blending of SMALL AMOUNT of powder by movement of a pharmaceutical spatula through them on a sheet of paper or ointment tile

A

spatulation

33
Q

mixture that MELTS AT LOWER TEMPERATURE than any other ingredients when enclosed and prolonged contact with one
another

A

eutectic mixture

34
Q

not suitable for large quantities of powder and not recommended for
powders containing potent substances

A

spatulation

35
Q

provides INTIMATE blending of powders

A

trituration

36
Q

types of mortar used in trituration

A

Porcelain, Wedgewood, or glass

37
Q

ROUGH inner surface is preferred than a glass mortar with a smooth working surface

A

porcelain or ceramic mortar

38
Q

preferred for CHEMICAL THAT STAINS that stains porcelain or ceramic surface as well as for simple admixture of substance without special need for comminution

A

glass mortar

39
Q

CLEANS READILY after use and trituration is not recommended
for eutectic mixtures

A

glass mortar

40
Q

for MIXING POTENT SUBSTANCES with a large amount of diluent

A

geometric dilution

41
Q

placed on APPROX EQUAL VOLUME or amount of diluent in a mortar and mixed by trituration

A

potent drug

42
Q

recommended or indicated on instances in which the potent and non-potent substance are of the same color and visible sign of thorough mixing is lacking

A

geometric dilution

43
Q

SIMPLEST and probably most COMMONLY used method for mixing powders or particle size determination

A

sifting method

44
Q

powders are mixed by passing them through sifters like the type used in the kitchen to sift flour

A

sifting method

45
Q

Sifting results in a ____________________________

A

light, fluffy product

46
Q

not acceptable for incorporating potent drugs into a diluent
base

A

sifting method

47
Q

tumbling the powder in a rotating
chamber

A

tumbling

48
Q

mixing powder in a large enclosed container, ROTATED by a
motorized process

A

tumbling

49
Q

V-blended and twin shell blender

A

tumbling instruments

50
Q

study of small particles

A

micromeritics

51
Q

T/F: It is very important to study particles because MOST drug dosage forms are SOLIDS

A

True

52
Q

Solids are not ___________ systems

A

static

53
Q

REDUCING particle size with a FINER state of subdivision

A

comminution

54
Q

Considerations in Comminution and Blending of powders

A
  1. quantity
  2. equipment available
55
Q

particle size determination

A
  1. sieving
  2. coulter counter
  3. microscopic analysis
  4. sedimentation rate
  5. light scattering
  6. laser diffraction analyzer
  7. laser halography
56
Q

good source of Sodium,
Potassium and chloride

A

sodium chloride and potassium chloride

57
Q

helps correct the
subsequent metabolic
acidosis caused by diarrhea
and dehydration

A

sodium bicarbonate

58
Q

glucose transport is
coupled with sodium
absorption

A

anhydrous glucose

59
Q

Electrolytes should be expressed in ______

A

mEq

60
Q

side effects of ORS

A

nausea and vomiting

PHA6124 LAB Manufacturing Pharmacy (3 decks)

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