alterations in body temp Flashcards
(21 cards)
mean oral temperature for healthy individuals 18-40
36.8deg +/- 0.4
98.2F +/- 0.7
low and high levels of body temp occurs at what time
low levels - 6am
high level - 4-6pm
max oral temp
37.2 - 6am
37.7 - 4pm
rectal temp
generally 0.4c higher than oral
center of controlled body temp
hypothalamus
both signals are integrated by the ______ on the hypothalamus to maintain normal temperature
thermoregulatory center
transmit information from warmth/cold receptors in the skin
peripheral nerves
women who menstrate, the AM temp is generally lower in ___ before ovulation
rises by ___ with ovulation and remains at that level until menses occur
2 weeks
0.6C
defines when the temperature is > 41.5C = >106.7 F
hyperthermia
hyperthermia is more common in patients with?
severe infection, CNS hemorrhage
is not a fever but uncontrolled increase in the body temp that exceeds the body ability to lose heat
heat stroke
it is fatal and does not respond to antipyretics
heat stroke
pathogens of fever
PYROGENS
- exogenous
- endogenous
ELEVATION OF THE HYPOTHALAMIC SET POINT BY CYTOKINES
are now called pyrogenic cytokines
endogenous
a. IL-1, IL-6
b. Tumor necrosis factor
c. cilliary neurotropic factor
d. interferon
inhibition of cyclooxygenase will decrease the synthesis of prostaglandins
antipyretic agents
-aspirin
-acetaminophen
-NSAIDS, COX-3
-glucocorticoids
refer to any febrile illness without an initially obvious etiology
fever of unknown origin
new definition of fever of unknown disease
> 38C
illness duration of 3 weeks or more
no known immunocompromise state
diagnosis that remains uncertain after a thorough tests
etiology of fever of unknown origin
infection
-bacterial, non specific
-bacterial, specific
-fungal
-parasitic
-viral
non infectious inflammatory disease
-systemic rheumatic and auto immune disease
-vasculitis
-granulomatous disease
-autoinflammatory syndrome
neoplasm
-hematologic malignancies
-solid tumors
-benign tumors
miscellaneous
thermoregulatory disorders
-central
-peripheral
characteritzed by an elevated body temp t hat is associated with moderate to strenous exercise lasting from half an hour up to several hours without an increase in CRP or ESR
exercise induced fever
allopurinol, carbamazepine, phenytoin,sulfazalaine, furosemide, antimicrobial drugs such as sulfonamides, minocycline,vancomycin, betalactam, isoniazid, quinidine
drug induced fever
fever artificially indecued by the patient
factitious fever
