Alzheimer's Disease

Question 1

2 pathological features of Alzheimer’s disease

Answer 1

Amyloid plaques

Neurofibrillary tangles

Question 2

What brain neurotransmitters are decreased in Alzheimer’s?

Answer 2

Serotonin, acetylcholine, norepinephrine

Question 3

What levels are usually elevated in Alzheimer’s?

Answer 3

Glutamate

Question 4

What are the two classes of drugs to treat Alzheimer’s?

Answer 4

Acetylcholinesterase inhibitors

NMDA antagonists

Question 5

3 acetylcholinesterase inhibitors in clinical use to treat Alzheimer’s?

Answer 5

Donepezil, Galantamine, Rivastigmine

Question 6

NMDA antagonist drug to treat Alzheimer’s?

Answer 6

Memantine

Question 7

2nd generation, reversible cholinesterase inhibitor

Answer 7

Donepezil

Question 8

Slowly-reversible cholinesterase inhibitor targets both AChE & BuChE

Answer 8

Rivastigmine

Question 9

Galantamine MAO

Answer 9

Reversible AChE/BuChE inhibitor & stimulates pre-synaptic nicotinic receptors

Question 10

Half life of donepezil

Answer 10

70 hours

Question 11

Half life of Rivastigmine

Answer 11

1-2 hours

Question 12

Net effect of Memantine

Answer 12

Elevate tonic levels of glutamate

Question 13

Natural chemical found in turmeric Alzheimer’s disease?

Answer 13

Curcumin