Alzhiemer's Therapy Flashcards
(14 cards)
What is Exelon?
Cholinasterase Inhibitors
Other Cholinesterases?
Exelon, Aricept and Reminyl
What is added to therapy as disease progesses?
Anti-depressants and mood stabilisers.
Current AD therapies?
Cholinesterases Inhibitors and NMDA receptor antagonist.
NMDA receptor Antagonist?
Ebixa
Why did gamma-secretases work?
Dont just target A-beta, target Notch, beta-subunits, voltage-gated Na+ channels.
Why do Rheumatoid Arthritis patients have less AD?
NSAIDs reduce AB42 production.
Are NSAIDs viable therapy?
Failed P3 trails
Link with Cholesterol and AD?
Apolipoprotein E4 involved in cholesterol transport is more prevalent in AD patients.
A-beta degrading enzymes?
IDE activation, Plasma activation, ECE-1 activation, ACE activation and Angiolensin.
Active Immune therapy?
AN1792 and ACC-001 failed p2 trials
Passive Immune Therapies?
Bapineuzumab, monoclonal antibodies. Pfizer and LY2062430 failed p2 trials
Anti-aggregation therapies?
Alzhemend failee p2 trials. Clonquinol in p2 now.
alpha-secretase therapies?
Cholinesterase Inhibitors, Muscarinic agonists, PKC activators and PACAP.
