Dementia Pathology Flashcards
(7 cards)
1
Q
Name 7 clinical symptoms?
A
Amnesia, Aphasia, Agnosia, Apraxia, Visuspatial, Psychosis, personality changes.
2
Q
What is brain pathology of AD?
A
Neurofibrillary tangles and senile plaques.
3
Q
What are plaques cause by?
A
Amyloid beta peptide.
4
Q
What causes A-beta plaque?
A
Beta-secretase and gamma secretase proccessing of APP.
5
Q
What does B-secretase do?
A
Cleaves APP at met-asp bond at N-terminal.
6
Q
What does alpha secretase do?
A
Creates ADAM17
7
Q
Why are amyloid fibrils neurotoxic?
A
BInd to neurons and cause toxicity
