AMIODARONE Flashcards Preview

YEAR 3 DRUGS > AMIODARONE > Flashcards

Flashcards in AMIODARONE Deck (9)
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1
Q

Drug class

A

anti-dysrhythmics

2
Q

How does it work? (2)

A
  1. blocks sodium, calcium and potassium channels in myocardial cells
  2. antagonises alpha and beta cells in the heart
3
Q

What effect does amiodarone have on the body? (4)

A
  1. reduces spontaneous depolarisation
  2. slows downs conduction
  3. increases resistance to depolarisation - AV node
  4. consequently reducing ventricular rate
4
Q

How does amiodarone work in SVT? (2)

A
  • breaks a self-pertuating circuit that includes the AV node

- this restores sinus rhythm

5
Q

Indications

A

tachyarrythmias

6
Q

Contra-indications (3)

A
  1. bp
    - severe hypotension
  2. heart
    - heart block
  3. thyroid
    - active thyroid disease
7
Q

Side effects (6)

A
  1. bp

– hypotension during IV infusion

  1. lungs
    - pneumonitis
  2. heart
  • bradycardia
  • AV block
  1. liver
    - hepatits
  2. skin
  • photosensitivity
  • grey colour
  1. thyroid abnormalities
  • due iodine content
  • amIODarone -iodine is in the name
8
Q

Interactions (3) and what does it cause? (4)

A
  1. digoxin
  2. verapamil
  3. diltiazem

-increases plasma concentration

causes

  • bradycardia
  • AV block
  • heart block
9
Q

Elimination (2)

A
  1. hepatic metabolism

2. bilary