RAMIPRIL Flashcards
1
Q
Drug class
A
ACE inhibitor
2
Q
How does it work? (2)
A
- block the action of ACE
2. this prevents the conversion of Angiotensin I to Angiotension II
3
Q
What does Angiotensin II do? (2)
A
- it is a vasoconstrictor
- it stimulates aldosterone secretion
4
Q
What does blocking Angiotensin II do? (2)
A
- reduces peripheral vascular resistance (after load)
- hence lowering blood pressure
5
Q
How do ACE inhibitors work in CKD? (3)
A
- dilates the efferent glomerular arteriole
- reducing the intraglomerular pressure
- slowing CKD
6
Q
How do ACE Inhibitors promote sodium and water excretion? (3)
A
- they prevent angiotensin II production
- Angiotensin II is involved in the production of aldosterone
- reducing the production of aldosterone promotes the excretion of sodium and water
7
Q
How are ACE Inhibitors beneficial for heart failure?
A
- reduces venous return (preload)
8
Q
Indications (3)
A
- heart
- heart failure
- ischaemic heart disease
- hypertension
- kidneys
- CKD with proteinuria
- diabetic nephropathy
9
Q
Contra-indications (2)
A
- pregnancy and breast feeding
- kidneys
- AKI
- CKD - low doses
- renal artery stenosis
10
Q
Side effects (4)
A
- kidneys
- renal failure - hypotension - 1st dose
- ion imbalance
- hyperkaelemia - chronic cough
- bradykinin
11
Q
Interactions (2)
A
- NSAIDs
2. potassium elevating drugs
12
Q
Eliminations (2)
A
- urine - 60%
2. faeces - 40%
