amlodipine

Question 1

what type of drug

Answer 1

dihydropyridine CCB

Question 2

MOA of dihydropyridine CCBs

Answer 2

relax AM and dilate coronary and peripheral arteries

Question 3

indications of CCBs

Answer 3

hypertension

prophylaxis of angina

Question 4

s/e common with amlodipine

Answer 4

ankle swelling with amlodipine 10mg (common in higher doses)

Question 5

interaction with CCBs

Answer 5

grapefruit juice

inc plasma concs of CCBs including verapamil, nifedipine, lercanipidine

Question 6

verapamil/diltiazem vs dihypropyridine CCBs (amlodipine, lercanipidine, nifedipine)

Answer 6

verapamil & diltiazem AVOIDED in HF
- further depress cardiac fxn
- significant patient deterioration

avoid verapamil with beta blockers (diltiazem used with caution)