Amylase Flashcards by Kim Cabel

Q

Other name of AMY

A

Alpha 1-4-Glucan-4-Glucohydrolase

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Q

Amy catalyzes breakdown of

A

Starch and glycogen

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Q

Starch contain

A

Amylose and amylopectin

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Q

Degrade, produce glucose, maltose and intermediate chain

A

Alpha amylose

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Q

Intermediate chain

A

Dextrins

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Q

Required for activation

A

Ca and Cl ions

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Q

Major tissue sources of serum

A

Acinar cells of pancreas and salivary glands

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Q

Earliest pancreatic marker

A

Amylase

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Q

Performs major digestion action

A

Pancreatic amy

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Q

Inactivated by

A

Acidity of gastric content

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Q

Smallest enzyme

A

Amy

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Q

MW

A

50,000-55,000 D

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Q

Rise

A

5-8 hrs

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Q

Peak time

A

24 hrs

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Q

Return to normal

A

3-5 days

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Q

Values general range

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A

250-1000 somogyi units per dL

Q

Occurs is neoplastic disease

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A

Hyperamylasemia

Q

Results to urine amy abnormally LOW

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A

Macroamylasemia

Q

2 major bands and 4 minor bands can be seen in

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A

Normal human serum

Q

P-type

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A

Pancreatic type amylopsin

Q

S-type

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A

Salivary ptyalin

Q

What type migrate most quickly

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A

S1
S2
S3

Q

Slower types

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A

P1
P2
P3

Q

Migrates to beta to alpha globulins

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A

Isoamylase

Most commonly observe fraction

P1 S1 S2

In acute pancreatitis, it is the most predominant

P3

Approx 2/3 of AMY in normal serum

S type

4 main approaches

Amyloclastic Saccharogenic Chromogenic Conrinuous monitoring

Loss of activity at

RT for 1 week Or 4c for 2 months

Coversion factor

1.85

Amy serum

28-100 U/L

Amy urine

1-15 U/h

Leads to falsely elevated of AMY

Morphines and opiates

Suppress or inhibit serum amy activity

Plasma TG