Creatine Kinase

Question 1

MW

Answer 1

82,000 D

Question 2

Class of enzyme

Answer 2

Transferase

Question 3

Associated with

Answer 3

ATP regeneration

Transport system

Question 4

Transfase of phosphate group PO4

Answer 4

Kinase

Question 5

Ami

Answer 5

Acute myocardial infarction

Question 6

Cns shock

Answer 6

Sepsis

Question 7

High concentration in

Answer 7

Skeletal muscle
Heart muscle
Brain tissue

Question 8

Sensitive indicator for

Answer 8

Ami

Md-duchenne type

Question 9

Also seen in CNS disorder such as

Answer 9

Stroke, nerve degeneration, seizures, cns shock

Question 10

2 subunits

Answer 10

H and M

Question 11

Isoenzymes

Answer 11

Ck bb-brain type
Ck mb- hybrid type
Ck mm- muscle type

Question 12

Fastest iso

Answer 12

Ck bb

Question 13

Slowest iso

Answer 13

Ck mm

Question 14

Most predominant iso in healthy individuals

Answer 14

Ck mm

Question 15

Ck mm found in

Answer 15

Striated muscle and normal serum

Question 16

Heart muscle activity mostly

Answer 16

80% ck mm

20% ck mb

Question 17

Hypothyroidism

Answer 17

Ck mm

Question 18

High conc in brain

Answer 18

Ck bb

Question 19

Seen in cns, git, uterus

Answer 19

Ck bb

Question 20

Pregnancy

Answer 20

Ck bb

Question 21

Ck bb used to detect

Answer 21

Cns damage
Childbirth
Tumor

Question 22

Hypothyroidism result to ck mm decrease or elevate?

Answer 22

Elevate

Question 23

Ck mb not increase

Answer 23

Angina pectoris

Question 24

Bedridden patients increase or decrease ck activity

Answer 24

Decrease

Question 25

Major iso

Answer 25

Ck mm

Question 26

If patient undergone a vaccination and submit herself for a ck test, what could be the results?

Answer 26

Elevate

Question 27

Increase within what range of hrs

Answer 27

4-8 hrs

Question 28

Peak time

Answer 28

12-24 hrs

Question 29

Return to normal in

Answer 29

48-72 hrs

Question 30

Used as more sensitive and specific marker for myocardial damage

Answer 30

Troponin I and T

Question 31

2 atypical forms

Answer 31

Macro ck | Mitochondrial c

Question 32

Appears in severe illness

Answer 32

Mitochondrial c

Question 33

Appears in age and gender

Answer 33

Macro ck

Question 34

Reference method for ck

Answer 34

Electrophoresis

Question 35

More sensitive and precise than electrophoresis

Answer 35

Ion exchange chromatography

Question 36

Enzyme released by rbc

Answer 36

Adenylate kinase

Question 37

Used to inhibit ak in hemolyzed sample

Answer 37

Amp

Question 38

Do not have ck

Answer 38

Liver cells | Rbc

Question 39

Most anodal and labile

Answer 39

Ck bb

Question 40

Least anodal

Answer 40

Ck mm

Question 41

Potent inhibitors

Answer 41

Urate | Cysteine

Question 42

Buffer

Answer 42

Imidazole

Question 43

Assays

Answer 43

Tanzer gilbarg | Oliver rosalki

Question 44

Forward rxn ph

Answer 44

9

Question 45

Reverse rxn ph

Answer 45

6.8

Question 46

Most commonly performed method in ck

Answer 46

Oliver rosalki

Question 47

Does hemolysis elevate or decrease ck?

Answer 47

Elevate

Question 48

Serum is inactivated by

Answer 48

Light and ph

Question 49

Serum should be kept at

Answer 49

Dark place

Question 50

Restores lost ck activity

Answer 50

Cleland reagent | Glutathione

Question 51

Stored in

Answer 51

4c (7days) | -20 (1 month)

Question 52

Reference range in male and female

Answer 52

M: 46-171 U/L F: 34-145 U/L

Question 53

It is added to reverse reverse method to inhibit ak

Answer 53

Adenosine monophosphate

Question 54

Expression of the percentage of total ck

Answer 54

Ck relative index