Amyloidosis Flashcards Preview

Pathology > Amyloidosis > Flashcards

Flashcards in Amyloidosis Deck (8)
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1
Q

Most common affection in systemic form of amyloidosis

A

Kidney - nephrotic syndrome and/or progressive renal failure
Heart - restrictive cardiomyopathy, arrhythmia, CHF

2
Q

Amyloid protein and fibrillary protein in primary amyloidosis. Associated with which conditions?

A
  • AL
  • kappa, lambda light chains of Ig
  • plasma cell disorder, multiple myeloma
3
Q

Amyloid protein and fibrillary protein in secondary amyloidosis, what type of diseases can you see related with it?

A
  • AA
  • serum amyloid A (SAA)
  • neoplasia and chronic inflammatory (SLE, RA, Chron, etc)
4
Q

Amyloid protein AA, fibrillary protein SAA, autosomic recessive, neutrophilic dysfunction, recurrent fever

A

Familial Mediterranean fever

5
Q

Amyloid protein and fibrillary protein in hemodialysis-associated amyloidosis (end stage Renal disease). Clinical presentation associated.

A
  • ABeta2M
  • Beta2-microglobulin
  • carpal tunnel syndrome
6
Q

Type of amyloid protein and fibrillary protein in Alzheimer

A
  • ABeta

- beta-amyloid precursor protein (BAPP)

7
Q

Amyloid protein and fibrillary protein in senile cardiac amyloidosis

A
  • ATTR

- transthyretin (TTR) [wild-type normal protein]

8
Q

Amyloid and fibrillary protein deposition in heritable amyloidosis. How is the manifestation?

A
  • “ATTR”
  • mutated transthyretin (TTR)
  • Familial amyloid polyneuropathies