Renal Pathology Flashcards
(20 cards)
Why do lipiduria and hyperlipidemia occur in nephrotic syndrome?
Compensate protein lose
What is the “lumpy bumpy” pattern in primary glomerulonephritis? In which pathology can you see it?
- granular deposits of IgM, IgG, C3 through glomerulus
- APSGN
Characteristic finding in rapidly progressive glomerulonephritis
Crescents within bowman space
Pathologies associated with IgA nephropathy (Berger disease)
- celiac sprue
- Henoch-Schölein purpura
Which GN can rise nephrotic and nephritic syndrome, or mixed?
Membranoproliferative glomerulonephritis
Characteristic finding in type I membranoproliferative GN at light microscopy
“Tram-tracking”
What suggest presence of C3 nephritic factor?
Type II MPGN
Most common cause of nephrotic syndrome in children
Minimal change disease
Which finding in electron microscopy do the nephrotic primary glomerulonephritis have in common?
Effacement of (epithelial) podocytes foot processes
Primary glomerulopathy that yields nephrotic syndrome and has a poor response to steroids
Focal segmental glomerulosclerosis
Most common cause of acute renal failure in USA
Acute tubular necrosis
Most common cause of nephrotic syndrome in children
Minimal change disease
Which finding in electron microscopy do the nephrotic primary glomerulonephritis have in common?
Effacement of (epithelial) podocytes foot processes
Primary glomerulopathy that yields nephrotic syndrome and has a poor response to steroids
Focal segmental glomerulosclerosis
Most common cause of acute renal failure in USA
Acute tubular necrosis
Three microscopy components of Wilms tumor
- metanephric blastema
- epithelial elements (immature glomeruli, tubules)
- stroma
Drug cause of hemorrhagic cystitis
Cyclophosphamide
How do you differentiate clinically renal cell carcinoma and transitional cell carcinoma?
- RCC: hematuria, flank pain and palpable mass
- Transitional cell carcinoma (renal pelvis, ureter, bladder): painless hematuria
Pathology associated with Kimmelstiel-Wilson lesions at light microscopy
Diabetic glomerulonephropathy
Common complications of nephrotic syndrome
- antithrombin III loss in urine ▶️ hypercoagulable state (ex thromboembolism)
- loss of immunoglobulins in urine ▶️ risk of infection
- edema ▶️ soft tissue compromise
