Anaesthesia in animals with pre-existing disease Flashcards

1
Q

What is the monroe Kellie hypothesis?

A

Is a pressure-volume relationship that aims to keep a dynamic equilibrium amoung the essential non-compressible components inside the rigid compartment of the skull

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

When may the blood brain barrier be disrupted?

A

Trauma
Inflammation
Hypertension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What % of the co does the brain receive and why?

A

15% because it has a high metabolic rate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is intercranial pressure influenced by?

A

Cerebral perfusion pressure
PaCO2
PaO2
Cerebral metabolic activity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the cushings reflex?

A

Nervous system response to increased intercranial pressure
Cushings traid of increased blood pressure
Irregular breathing
Bradycardia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What can be used to reduce intercranial pressure?

A

Mannitol osmotic diuresis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the clinical signs of increased intercranial pressure?

A
Seizures 
Odema around the optic nerve 
Subdued 
Depressed mentation
Reluctant to move
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is cerebral percussion pressure and what can it be influenced by?

A

Pressure gradient between MAP and ICP
Cerebral blood flow is autoregulated MAP 50-150mmhg
Coughing, vomiting, pressure on the jugulars increases venous outflow pressure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Why is it important to control PaCO2 in a neuro patient?

A

Every 1mmhg increase in co2 there’s a 4% increase in cerebral blood flow

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

At what parameters should you maintain CO2 at during anaesthesia for a neuro patient?

A

30-45mmhg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What steps may you take to decrease CO2 during anaesthesia in a neuro patient?

A

Ventilate

Pre-oxygenate before surgery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What should be avoided when placing an ET tube in a neuro patient?

A

Coughing raises ICP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is intracerebral steal?

A

Damaged area loses ability to autoregulate whenundamged are vasodilates blood is shunted away from damaged area

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is inverse steal in the brain?

A

Damaged areas cannot auto-regulatevasoconstriction if un damaged area leads to blood shunted towards the damaged areas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Why should hypoxia be avoided in a neuro patient?

A

It will cause dilation

Consider 100% oxygen for recovery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Why should hypothermia and barbiturates be avoided in a neuro patient?

A

Will decrease cerebral activity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What are the effects of ACP and dexmedotomidine and which one should be used in a neuro patient?

A

Dexmeditomidine
Initial hypertension maintains MAP below 150mmHg
Cerebral protection
Can get vomiting
Acepromazine
Peripheral vasodilation can increase cerebral blood flow and intercranial pressure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Which inhalation agent should be used in a neuro patient and why?

A

Sevoflurane

Cerebral protectant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Why should neuro patients be handled and positioned carefully?

A

Harness to reduce pressure on jugular veins

Keep head elevated to improve cerebral venous drainage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Why should fluid balance be carefully monitored in the neuro patient?

A

Hypertension can increase intercranial pressure

Hypotension can limit the blood supply to the brain (vasodilation)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What should also be monitored for in the neuro patient?

22
Q

How should an anaesthetic patient be monitored if they have a clinical history of seizures?

A

Be aware of the current medication
Phenobarbital can induce hepatica enzymes
Potassium bromide causes and electrolyte abnormality
Iv carheter essential
Close monitoring before and after anaesthesia
Capnography
Blood presure

23
Q

What must be considered when anaesthetising a neuromuscular disorder patient?

A

Pre-disposed to regurgitation and aspiration
Check gag reflex
May affect respiratory muscles
Capnography may require IPPV

24
Q

What is important to consider when anaethetising and myasthenia graves patient?

A

Exxagerated response toNMB agents

25
What is important to consider in patients being anaesthetised who have an oesophageal foreign body?
Tube may be damaged during surgery or need to be removed Stabilisation before Dehydration( not been able to drink) Potential for regurgitate and aspiration Pre-oxygenation Suction available Keep the head elevated until the ET tube is inserted and cuff inflated Possible rupture of the oesopagus Analgesia
26
What are important considerations for the GI foreign body anaesthetised patient?
``` Fluid balance disruptions hypovolamia acid base electrolytes dehydration Avoid vomiting inducing drugs Potential regurgitate and aspiration Slow release of fluid from the abdomen Hypothermia Monitor respiratory rate carefully ```
27
What are the considerations for the GDV patient undergoing anaesthesia?
``` Shock, stabilise first fluids Decompress stomach Arrhythmias Careful monitoring cardiovascular system Hypotension Pressure on the diaphragm from distended viscous Clotting abnormalities Possible pneumothorax Intensive post-op care ```
28
What are the important considerations for the colic surgery horse being anaesthetised?
``` Electrolyte and acid base imbalance Hypovolameia shock Dehydration Cardiovascular arrhythmia Very painful! Analgesia-NSAIDs, Xylazine, opioids Decompress stomach Distended viscera pressure on the lungs risk of rupture Endotoxamia Fluids-Hartmanns, 7.5% Nacl, colloids ```
29
What conditions can affect the livers function?
Acute liver failure Portosystemic shunt Billary tract obstruction/trauma Chronic disease
30
What is the livers function?
``` Clotting factors Production plasma proteins Drug and hormone bio transformation Bilirubin excretion Urea production 80% of the blood supply passes through the portal vein ```
31
What are liver patients at risk of during surgery?
Hypothermia Hypoglycemia Haemorrhage Increased free fraction of drugs (less plasma proteins to bind to) Decreased hepatic clearance of drugs Water and sodium retention, potassium loss
32
What are the effects of anaesthesia on the liver function?
Hypotension-decreased perfusion Hepatotoxicity Enzyme induction
33
Pre-anaesthetic laboratory tests required for the liver
``` Liver enzymes Bile acids Clotting function Urea Plasma proteins Glucose ```
34
What are the general considerations for a anaethetised liver patient?
``` Thermoregulation Medical management encephalopathy Monitor blood glucose Blood pressure Maintain adequate renal perfusion Monitor blood loss Avoid hypoxia and hyopercapnia CVP Use of short acting drugs Monitor individual animal response ```
35
What considerations should you make for an anaethetised insulinoma patient?
``` Monitor glucose 5% dextrose infusion Pain!! Medical management-prednisalone, diaoxide, glucose Avoid hyperglycaemia and hypoglycemia May consider NMB agent Post-operative pancreatitis ```
36
What considerations must we make for a diabetic patient undergoing anaesthesia?
Stabilise prior to surgery- ketosis, dehydration, weight loss, fatty liver Feed asap after surgery Postpone fasting for as long as possible Glucose infusion if required Avoid hypoglycemia and hyperglycaemia Monitor temperature Give half dose insulin before the procedure then half dose once eaten afterwards Know the routine at home (favourite food) 1st patient of the day Fluids include glucose Avoid medetomidine(hyperglycemia) Good analgesia Short acting drugs Poss 2nd iv
37
What considerations should we make for the anaesthetised hyperthyroid patient?
``` Difficult to handle Easily stressed IM sedation then IV Sedation with opioids and ACP Avoid ketamine and medetomidine Iv induction Consider chamber Iv fluids Monitor ECG Fast metabolism Prone to hypothermia PUPD Thin Muscle weakness Hypertrophic cardiomyopathy ```
38
What considerations should we make for the anaesthetised patient undergoing a thyroidectomy?
``` Monitor blood pressure Monitor other parameters for depth of anaesthesia as surgery located at the head end Potential laryngeal paralysis post op Monitor for hypocalcemia Keep Iv in and patent ```
39
What considerations should we make during anaesthesia for the hypothyroid patient
``` Prone to hypothermia May have megaoesophagus Decreased GI motility Obesity Lethargy Bradycardia and hypotension Slow biotransofrmation of drugs ```
40
What considerations should we make for hyperadrenocortisim?
``` Cushings Poor muscle tone Overweight Lethargic Poor thermoregulation Bruising Risky of pulmonary thromboembolism Hypercoagulability PUPD sodium retention potassium excretion Risk of wound infection and dehiscence ```
41
Hypoadrenocortisim considerations for the anaesthetised patient?
``` Addisions Lack of cortisol production. Hyperkalaemia Dehydration Bradycardia Weight loss Weakness Lethargy Stabilise before anaesthetic ```
42
Why is jaundice a problem in the anaesthetised patient?
Neohrotoxic
43
Why might hypoalbmenia be a problem in an anaesthetised patient?
More free fraction of drugs | Albumin binds the anaesthetic drugs
44
Why may hypotension be a problem in the liver diseases anaesthetised patient?
Reduced hepatic perfusion | Hepatocellular compromise
45
What drug is recommended for analgesia in the liver patient?
Pethidine usually lasts 1-2 hours can last up to 24 hours in a hepatic compromised patient
46
What other drug should be avoided if an insulinoma patient is already receiving prednisalone?
NSAIDS
47
What may hyperthyroid cats be predisposed to before surgery?
Arrhythmia
48
What does obesity increase the risks of in anaesthesia?
Ventilation compromised | Regurgitate and aspiration
49
What is it important to encourage a hyperadrenocortisim patient to do after surgery?
Mobilise
50
What is an hypoadrenocortisim patient unable to do?
Mount a stress responses