Analgesic Drugs Flashcards
(144 cards)
1
Q
What is the drug class of Aspirin?
A
Nonsteroidal Anti-Inflammatory Drug (NSAID)
2
Q
What is the mechanism of action of Aspirin?
A
Irreversible inhibition of COX-1 and COX-2 by covalent acetylation
3
Q
What are the drug targets of Aspirin?
A
Cyclooxygenase enzymes (COX-1 and COX-2)
4
Q
What is the expected time for effect of Aspirin?
A
Varies based on dosage and condition being treated
5
Q
What are the pharmacodynamics of Aspirin?
A
Anti-platelet aggregation at low doses, antipyretic and analgesic at intermediate doses, anti-inflammatory at high doses
6
Q
What are the pharmacokinetics of Aspirin?
A
Absorbed completely, negligible first-pass hepatic metabolism, tightly bound to serum proteins, small volume of distribution
7
Q
What is the absorption of Aspirin?
A
Complete
8
Q
What is the distribution of Aspirin?
A
Small volume of distribution
9
Q
How is Aspirin excreted?
A
Renal
10
Q
What is the metabolism of Aspirin?
A
Hepatic
11
Q
What are the dosage ranges for Aspirin?
A
Low doses (< 300 mg/day), intermediate doses (300-2400 mg/day), high doses (2400-4000 mg/day)
12
Q
What are key facts about Aspirin?
A
Avoid in patients with gout, risk of Reye syndrome in children with viral infections
13
Q
What is the drug class of Celecoxib?
A
Selective COX-2 Inhibitor (NSAID)
14
Q
What is the mechanism of action of Celecoxib?
A
Reversible inhibition of COX-2
15
Q
What are the drug targets of Celecoxib?
A
COX-2 enzyme
16
Q
What is the expected time for effect of Celecoxib?
A
Varies based on dosage and condition being treated
17
Q
What are the pharmacodynamics of Celecoxib?
A
Anti-inflammatory and analgesic
18
Q
What are the pharmacokinetics of Celecoxib?
A
Absorbed completely, negligible first-pass hepatic metabolism, tightly bound to serum proteins, small volume of distribution
19
Q
What is the absorption of Celecoxib?
A
Complete
20
Q
What is the distribution of Celecoxib?
A
Small volume of distribution
21
Q
How is Celecoxib excreted?
A
Renal
22
Q
What is the metabolism of Celecoxib?
A
Hepatic
23
Q
What are the dosage ranges for Celecoxib?
A
Varies based on condition being treated
24
Q
What are key facts about Celecoxib?
A
Less gastrointestinal bleeding compared to non-selective NSAIDs
25
What is the drug class of Meloxicam?
Selective COX-2 Inhibitor (NSAID)
26
What is the mechanism of action of Meloxicam?
Reversible inhibition of COX-2
27
What are the drug targets of Meloxicam?
COX-2 enzyme
28
What is the expected time for effect of Meloxicam?
Varies based on dosage and condition being treated
29
What are the pharmacodynamics of Meloxicam?
Anti-inflammatory and analgesic
30
What are the pharmacokinetics of Meloxicam?
Absorbed completely, negligible first-pass hepatic metabolism, tightly bound to serum proteins, small volume of distribution
31
What is the absorption of Meloxicam?
Complete
32
What is the distribution of Meloxicam?
Small volume of distribution
33
How is Meloxicam excreted?
Renal
34
What is the metabolism of Meloxicam?
Hepatic
35
What are the dosage ranges for Meloxicam?
Varies based on condition being treated
36
What are key facts about Meloxicam?
Long-acting
37
What is the drug class of Diclofenac?
Nonsteroidal Anti-Inflammatory Drug (NSAID)
38
What is the mechanism of action of Diclofenac?
Reversible inhibition of COX-1 and COX-2
39
What are the drug targets of Diclofenac?
Cyclooxygenase enzymes (COX-1 and COX-2)
40
What is the expected time for effect of Diclofenac?
Varies based on dosage and condition being treated
41
What are the pharmacodynamics of Diclofenac?
Analgesic, antipyretic, and anti-inflammatory
42
What are the pharmacokinetics of Diclofenac?
Absorbed completely, negligible first-pass hepatic metabolism, tightly bound to serum proteins, small volume of distribution
43
What is the absorption of Diclofenac?
Complete
44
What is the distribution of Diclofenac?
Small volume of distribution
45
How is Diclofenac excreted?
Renal
46
What is the metabolism of Diclofenac?
Hepatic
47
What are the dosage ranges for Diclofenac?
Varies based on condition being treated
48
What are key facts about Diclofenac?
Short-acting
49
What is the drug class of Ibuprofen?
Nonsteroidal Anti-Inflammatory Drug (NSAID)
50
What is the mechanism of action of Ibuprofen?
Reversible inhibition of COX-1 and COX-2
51
What are the drug targets of Ibuprofen?
Cyclooxygenase enzymes (COX-1 and COX-2)
52
What is the expected time for effect of Ibuprofen?
Varies based on dosage and condition being treated
53
What are the pharmacodynamics of Ibuprofen?
Analgesic, antipyretic, and anti-inflammatory
54
What are the pharmacokinetics of Ibuprofen?
Absorbed completely, negligible first-pass hepatic metabolism, tightly bound to serum proteins, small volume of distribution
55
What is the absorption of Ibuprofen?
Complete
56
What is the distribution of Ibuprofen?
Small volume of distribution
57
How is Ibuprofen excreted?
Renal
58
What is the metabolism of Ibuprofen?
Hepatic
59
What are the dosage ranges for Ibuprofen?
Varies based on condition being treated
60
What are key facts about Ibuprofen?
Short-acting
61
What is the drug class of Indomethacin?
Nonsteroidal Anti-Inflammatory Drug (NSAID)
62
What is the mechanism of action of Indomethacin?
Reversible inhibition of COX-1 and COX-2
63
What are the drug targets of Indomethacin?
Cyclooxygenase enzymes (COX-1 and COX-2)
64
What is the expected time for effect of Indomethacin?
Varies based on dosage and condition being treated
65
What are the pharmacodynamics of Indomethacin?
Analgesic, antipyretic, and anti-inflammatory
66
What are the pharmacokinetics of Indomethacin?
Absorbed completely, negligible first-pass hepatic metabolism, tightly bound to serum proteins, small volume of distribution
67
What is the absorption of Indomethacin?
Complete
68
What is the distribution of Indomethacin?
Small volume of distribution
69
How is Indomethacin excreted?
Renal
70
What is the metabolism of Indomethacin?
Hepatic
71
What are the dosage ranges for Indomethacin?
Varies based on condition being treated
72
What are key facts about Indomethacin?
Short-acting
73
What is the drug class of Ketorolac?
Nonsteroidal Anti-Inflammatory Drug (NSAID)
74
What is the mechanism of action of Ketorolac?
Reversible inhibition of COX-1 and COX-2
75
What are the drug targets of Ketorolac?
Cyclooxygenase enzymes (COX-1 and COX-2)
76
What is the expected time for effect of Ketorolac?
Varies based on dosage and condition being treated
77
What are the pharmacodynamics of Ketorolac?
Analgesic, antipyretic, and anti-inflammatory
78
What are the pharmacokinetics of Ketorolac?
Absorbed completely, negligible first-pass hepatic metabolism, tightly bound to serum proteins, small volume of distribution
79
What is the absorption of Ketorolac?
Complete
80
What is the distribution of Ketorolac?
Small volume of distribution
81
How is Ketorolac excreted?
Renal
82
What is the metabolism of Ketorolac?
Hepatic
83
What are the dosage ranges for Ketorolac?
Varies based on condition being treated
84
What are key facts about Ketorolac?
Short-acting
85
What is the drug class of Acetaminophen?
Analgesic and Antipyretic
86
What is the mechanism of action of Acetaminophen?
Inhibition of COX enzymes in the central nervous system
87
What are the drug targets of Acetaminophen?
Cyclooxygenase enzymes (COX-1 and COX-2)
88
What is the expected time for effect of Acetaminophen?
Varies based on dosage and condition being treated
89
What are the pharmacodynamics of Acetaminophen?
Analgesic and antipyretic
90
What are the pharmacokinetics of Acetaminophen?
Absorbed completely, negligible first-pass hepatic metabolism, tightly bound to serum proteins, small volume of distribution
91
What is the absorption of Acetaminophen?
Complete
92
What is the distribution of Acetaminophen?
Small volume of distribution
93
How is Acetaminophen excreted?
Renal
94
What is the metabolism of Acetaminophen?
Hepatic
95
What are the dosage ranges for Acetaminophen?
Varies based on condition being treated
96
What are key facts about Acetaminophen?
Risk of hepatotoxicity at high doses
97
What is the drug class of Glucocorticoids?
Corticosteroids
98
What is the mechanism of action of Glucocorticoids?
Inhibition of phospholipase A2 and suppression of immune response
99
What are the drug targets of Glucocorticoids?
Glucocorticoid receptors
100
What is the expected time for effect of Glucocorticoids?
Varies based on dosage and condition being treated
101
What are the pharmacodynamics of Glucocorticoids?
Anti-inflammatory and immunosuppressive
102
What are the pharmacokinetics of Glucocorticoids?
Absorbed completely, negligible first-pass hepatic metabolism, tightly bound to serum proteins, small volume of distribution
103
What is the absorption of Glucocorticoids?
Complete
104
What is the distribution of Glucocorticoids?
Small volume of distribution
105
How are Glucocorticoids excreted?
Renal
106
What is the metabolism of Glucocorticoids?
Hepatic
107
What are the dosage ranges for Glucocorticoids?
Varies based on condition being treated
108
What are key facts about Glucocorticoids?
Risk of adrenal suppression with long-term use
109
What is the drug class of Abatacept?
Immunomodulator
110
What is the mechanism of action of Abatacept?
Inhibition of T-cell activation
111
What are the drug targets of Abatacept?
CD80 and CD86 on antigen-presenting cells
112
What is the expected time for effect of Abatacept?
Varies based on dosage and condition being treated
113
What are the pharmacodynamics of Abatacept?
Immunosuppressive
114
What are the pharmacokinetics of Abatacept?
Absorbed completely, negligible first-pass hepatic metabolism, tightly bound to serum proteins, small volume of distribution
115
What is the absorption of Abatacept?
Complete
116
What is the distribution of Abatacept?
Small volume of distribution
117
How is Abatacept excreted?
Renal
118
What is the metabolism of Abatacept?
Hepatic
119
What are the dosage ranges for Abatacept?
Varies based on condition being treated
120
What are key facts about Abatacept?
Risk of serious infections
121
What is the drug class of Rituximab?
Monoclonal Antibody
122
What is the mechanism of action of Rituximab?
Binding to CD20 on B-cells
123
What are the drug targets of Rituximab?
CD20 on B-cells
124
What is the expected time for effect of Rituximab?
Varies based on dosage and condition being treated
125
What are the pharmacodynamics of Rituximab?
Immunosuppressive
126
What are the pharmacokinetics of Rituximab?
Absorbed completely, negligible first-pass hepatic metabolism, tightly bound to serum proteins, small volume of distribution
127
What is the absorption of Rituximab?
Complete
128
What is the distribution of Rituximab?
Small volume of distribution
129
How is Rituximab excreted?
Renal
130
What is the metabolism of Rituximab?
Hepatic
131
What are the dosage ranges for Rituximab?
Varies based on condition being treated
132
What are key facts about Rituximab?
Risk of serious infections
133
What is the drug class of Adalimumab?
Monoclonal Antibody
134
What is the mechanism of action of Adalimumab?
Binding to TNF-alpha
135
What are the drug targets of Adalimumab?
TNF-alpha
136
What is the expected time for effect of Adalimumab?
Varies based on dosage and condition being treated
137
What are the pharmacodynamics of Adalimumab?
Immunosuppressive
138
What are the pharmacokinetics of Adalimumab?
Absorbed completely, negligible first-pass hepatic metabolism, tightly bound to serum proteins, small volume of distribution
139
What is the absorption of Adalimumab?
Complete
140
What is the distribution of Adalimumab?
Small volume of distribution
141
How is Adalimumab excreted?
Renal
142
What is the metabolism of Adalimumab?
Hepatic
143
What are the dosage ranges for Adalimumab?
Varies based on condition being treated
144
What are key facts about Adalimumab?
Risk of serious infections
