analgesics table Flashcards by Caleb Houghton

Acetaminophen- APAP (Tylenol) - OTC dosing

325-1000 mg q 4-6 hours (maximum 3 gm/day OTC use, max 4 gm/day under
supervision of healthcare provider))

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APAP anti-inflam properties

none

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recomended APAP dose for older adults

2-3g/day

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child dosing APAP

see package

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who should we avoid APAP use in

Avoid use in patients with severe hepatic disease and
alcohol abuse/dependence

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what rx’s should be avoided when taking APAP

any others containing APAP

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NSAIDS anti inflam properties

Anti-inflammatory (at prescription strength/higher doses)

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NSAIDS general concerns:
May worsen?
increases?
causes?
decrease function of?

May worsen heart failure, increase BP, cause edema,
decrease kidney function

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Celecoxib (Celebrex) - RX dosing

Celecoxib (Celebrex) - RX 100- 200 mg BID

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celecoxib moa

selective cox 2 inhibitor

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celecoxib:
* GI?
* Caution/Contraindications in?

Lower risk of GI toxicities than non-selective NSAIDs.
Caution/Contraindications in CV disease, renal impairment, and high-risk GI bleed.

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Ibuprofen (Motrin) doses
OTC adult dose:
RX:

OTC adult dose: 200mg
RX: 400 mg, 600 mg, 800 mg

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Ibuprofen (Motrin) dosing

200 to 800 mg 3 to 4 times daily; usual dose: 400 mg;
usual daily dose: 1,200 to 2,400 mg/day

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ibuprofen moa

cox 1 and 2 inhibitor

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ibuprofen:
* increases risk of?
* Caution/Contraindications in?
* children dosing

increases risk of bruising and bleeding
Caution/Contraindications in CV disease, renal impairment and high-risk GI bleed.
See dosing/package information for children’s weight- based dosing

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Meloxicam (Mobic)- RX dosing

7.5- 15 mg daily

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meloxicam:
* increases risk of?
* Caution/Contraindications in?
* children dosing

increases risk of bruising and bleeding
Caution/Contraindications in CV disease, renal impairment and high-risk GI bleed.
See dosing/package information for children’s weight- based dosing

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Nabumetone (Relafen) - RX dosing

500 – 2000 mg daily

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Nabumetone:
* increases risk of?
* Caution/Contraindications in?
* children dosing

increases risk of bruising and bleeding
Caution/Contraindications in CV disease, renal impairment and high-risk GI bleed.
See dosing/package information for children’s weight- based dosing

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Naproxen/Naproxen Sodium
OTC adult dose:
RX:

OTC adult dose: 220 mg, as naproxen sodium
RX: 250mg, 500 mg

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Naproxen/Naproxen Sodium:
* increases risk of?
* Caution/Contraindications in?
* children dosing

increases risk of bruising and bleeding
Caution/Contraindications in CV disease, renal impairment and high-risk GI bleed.
See dosing/package information for children’s weight- based dosing

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non-selective NSAIDS

IBU
meloxicam
nabumetone
naproxen

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selective nsaids

celecoxib

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COMMON OPIOIDS AND OPIOID-LIKE AGENTS

Study These Flashcards

Acetaminophen and codeine (Tylenol #3/Tylenol#4)
Hydrocodone and acetaminophen
Oxycodone and acetaminophen
Oxycodone
Morphine Sulfate
Tapentadol (opioid like)
Tramadol and acetaminophen (opioid like)
tramadol (opioid like)

COMMON OPIOIDS AND OPIOID-LIKE AGENTS: Start with what doses?

Start with lower dose in opioid naïve patients (higher doses may be required in opioid tolerant patients).

opioids/opioid like: Common ADRs: May cause?

Common ADRs: sedation, constipation. May cause respiratory depression.

opioid/opioid like: Avoid use with>?

Avoid use with benzodiazepines, sedative-hypnotics, anxiolytics and other CNS depressants

forms of Acetaminophen and codeine

Tylenol #3: 300mg APAP, 30 mg codeine, Tylenol #4, 300 mg APAP, 60 mg codeine) C-III

Acetaminophen and codeine dosing

Acetaminophen (300 to 600 mg/dose)/codeine (15 to 60 mg/dose) every 4 hours as needed; adjust dose according to severity of pain and response of patient (maximum: acetaminophen 4,000 mg/codeine 360 mg per 24 hours

Acetaminophen and codeine high rate of what ADEs?

High rate of GI ADEs (especially constipation)

Acetaminophen and codeine analgesic effects?

limited

Acetaminophen and codeine and age precautions

Codeine is contraindicated in children younger than 12 yrs of age due to variability in metabolism. Caution in patients 12-18 years, especially those with potential for breathing problems such as those with obstructive sleep apnea or severe lung disease

Hydrocodone and acetaminophen formulations

* Hydrocodone 2.5 mg/APAP 335 mg, * Hydrocodone 5 mg/APAP 325 mg, * Hydrocodone 7.5 mg/APAP 325 mg, * Hydrocodone 10 mg/APAP 325 (others, somecontain 300 mg APAP) C-II

Hydrocodone and acetaminophen dosing

Hydrocodone 2.5 to 10 mg every 4 to 6 hours (maximum dose may be limited by the acetaminophen content of product)

what limits Hydrocodone and acetaminophen dosing

APAP content

Oxycodone and acetaminophen formulations

* oxycodone 2.5 mg/APAP 335 mg, * oxycodone 5 mg/APAP 325mg, * oxycodone 7.5 mg/APAP 325 mg, * oxycodone 10 mg/APAP 325 C-II

Oxycodone and acetaminophen dosing

2.5 to 10 mg every 4-6 hours as needed. Titrate according to pain severity and individual response. Maximum dose of limited by the acetaminophen content of product

what limits Oxycodone and acetaminophen dosing

APAP content

Oxycodone tablet doses

tablet - 5 mg, 15 mg, 30 mg C-II

Oxycodone tablet dosing

5 to 15 mg every 4 to 6 hours as needed

oxycodone tablets can be dosed with?

Able to dose with separate NSAID and/or acetaminophen

Morphine Sulfate tablet doses

15 mg, 30 mg C-II

Morphine Sulfate tablet dosing

15 to 30 mg every 4 hours as needed

how are opioids often measured

Opioids often compared by Mg Morphine Equivalents (MMEs)

Tapentadol (Nucynta) tablet doses

50 mg, 75 mg, 100 mg C-II

Tapentadol (Nucynta) tablet dosing

50-100 mg q 4-6 hrs

Tapentadol ADEs

* Opioid-like ADEs. * Decreases seizure threshold.

Tapentadol with adolescents

Safety and efficacy not established in patients < 18 years of age

Tramadol and acetaminophen formula

Tramadol 37.5 mg/APAP 325 mg C-IV

Tramadol and acetaminophen dosing

Two tablets q 4 -6 hours as needed for pain relief (maximum: 8 tablets/day)

Tramadol and acetaminophen ADEs

* Opioid-like ADEs. * Decreases seizure threshold.

Tramadol and acetaminophen caution use with?

* Caution when combined with other serotonergic medications. May precipitate serotonin syndrome * other products with APAP

Tramadol and acetaminophen dose limited by?

APAP content

Tramadol and acetaminophen use in kids/adolescents

Contraindicated in children younger than 12 yrs of age due to variability in metabolism. Caution in patients 12-18 years, especially those with potential for breathing problems such as those with obstructive sleep apnea or severe lung disease

Tramadol (Ultram) dose

50 mg C-IV

Tramadol (Ultram) dosing

50-100 mg q 4-6 hrs

Tramadol ADEs

* Opioid-like ADEs. * Decreases seizure threshold.

Tramadol caution use with:

Caution when combined with other serotonergic medications. May precipitate serotonin syndrome

tramadol use contraindicated in:

analgesics table Flashcards

(59 cards)