Anatomy of Neural Circuits Flashcards

1
Q

how could you section the brain?

A
  • sliced across 2 planes (front to back) can see 2 hemispheres
  • along the horizontal axis (2 parts of the brain are symmetrical)
  • sideways (not symmetrical)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what would a mid sagittal section look like?

A
  • forebrain compromises of cerebral hemispheres and diencephalon (CNS)
  • lower hind bran structures are the pons, medulla and cerebellum (CNS)
  • motor nerves (PNS)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what is the diencephalon?

A

thalamus and hypothalamus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

how does an MRI work?

A
  • nuclei of hydrogen atoms act as spinning magnets
  • strong magnetic field to align protons
  • burst of radio waves temporarily flips the protons out of alignment (return to state and emit energy)
  • energy is detected
  • hydrogen in different types of tissue have slightly different realignment rates
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what does the brain stem include?

A

the medulla, midbrain and bons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what is the brain stem?

A
  • evolutionary oldest brain regions
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what is the function of the brain stem?

A
  • automic
  • digestion, respiration, heart rate, blood pressure, swallowing
  • site of entry for sensory information
  • mediates arousal
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what does the pons do?

A

relays information from the cerebral cortex to the cerebellum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what is the function of the cerebellum?

A
  • recieves input of motor task to be performed and progress of ongoing skills
  • provides corrective skills and fine tunes movement
  • learning of motor skills
  • controls fine movement
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what is the structure of the cerebellum?

A
  • organised into 3 layers of cells
    1. granular layer
    2. purkinje layer
    3. molecular layer
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what is the cerebellum?

A

10% of brain volume but 50% of neurons

- evolutionary ancient

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

how can the cerebellums function be tested?

A

activation of the cerebellum during a bilateral finger tapping task which can be visualized by MRI –> fMRI activity superimposed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what does fMRI stand for?

A

functional MRI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what is fMRI?

A
  • depends on the fact that haemoglobin in blood distorts MRI properties of the spinning H atoms
  • amount of distortion depends on whether haemoglobin is carrying oxygen or not
  • measures areas where there are higher levels of oxygenated blood in the brain
  • increase blood flow to parts of the brain that are active
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what is the cerbral cortex?

A
  • most evolved brain structure (humans have a large cerebral cortex)
  • heavily wrinkled to allow lots of neurons
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what is the structure of the cerebral cortex?

A
  • 4 different lobes: frontal lobe, parietal lobe, occipital lobe, temporal lobe
  • organised into (6) cell layers which organise inputs and outputs
  • neurons of the brain are organised into circuits
17
Q

what is the function of the frontal lobe?

A

planning future action (pre-frontal cortex)

control of movement (motor cortex)

18
Q

what is the function of the parietal lobe?

A

somatic sensation

touch, pain and pressure

19
Q

what is the function of the occipital lobe?

20
Q

what is the function of the temporal lobe?

A

hearing
deep lying structures eg the hippocampus - learning and memory
emotion - amygdala
- regulating motor performance - basal ganglia

21
Q

what is the function of the cerebral cortex?

A
  • responsible for high order functions

- know more about neurons involved in sensory and motor than in processing language, memory or emotion

22
Q

why are neurons organsied into circuits?

A

so that the neurons for one particular function are in one neural system

23
Q

what diseases do problems in the basal ganglia lead to?

A

parkinsons or huntigdons disease

24
Q

what does emotion influence?

A

motivation behaviours

25
what are the key components of emotion?
1. physical sensation | 2. conscious feeling
26
what structures are responsible for physical sensation?
- Peripheral, autonomic, endocrine and skelomotor response | - Amygdala, hypothalamus and brain stem
27
what ares structures are responsible for conscious feeling/perception?
- Cortical structures: orbital and medial frontal lobes (prefrontal cortex)
28
what is function of the amygdala?
- required for fearful and pleasurable response - generates memories associated with emotional experiences - recieves information from the thalamus and sensory cortex
29
which structures does the amygdala work with for physical manifestation?
thalamus and brain stem
30
which structure does the amygdala work with for conscious feeling?
pre-frontal cortex
31
which structure does the amygdala work with for memory of the context?
hippocampus
32
how do you test fear conditioning?
- pair a sound with an electric shock - rat will learn to feat the sound - an associative memory - rodents with lesions in amygdala lack a conditioned fear response
33
who is patient SM?
- damaged amygdala but intact hippocampus - tested ability to rate intensity of human facial expressions - failed to recognize fear - damage was caused by Urbach-Weithe condition
34
what motivation and reward be driven by?
1. drive states directed towards maintaining physolical homeostasis (eg apeptite) 2. motivational states driven by rewarding/pleasurable and reinforcing stimulus (eg dont want bland food)
35
what is the reward pathway?
- stimuli signal the presence of reward by activating dopaminergic neurons in the VTA that project to the NuccAcc - this is the reward pathway
36
what is the VTA?
ventral tegmental area
37
what is the NucAcc?
nucleus accumbens
38
what acts on the reward pathway?
all addictive substances or behaviors activate this pathway