Androgens-valentovic

Question 1

Testosterone

Not through oral route, why?

Answer 1

Extensive first pass

Low bioavailability

Question 2

Testosterone

Topical

Application

Answer 2

24 h depot release (applied to shoulder and upper arm)

Question 3

Testosterone

Patch

Application

Answer 3

Applied daily

Local irritation causes compliance issues

Question 4

Testosterone

Patch

Application

Answer 4

Not to scrotum- to much testosterone absorption

Question 5

Testosterone

Patch

Caution…

Answer 5

Acne or abnormal hair growth in female partner

Question 6

Testosterone

Black box for gels and topicals

Answer 6

Virilization can occur in children exposed to topical testosterone

Question 7

Testosterone esters

Answer 7

Testosterone cypionate and enanthate

Question 8

Testosterone esters

Application

Answer 8

Administered IM: longer duration (2-4 wks)

Question 9

Testosterone esters

Indicated for

Answer 9

Hypogonadism

Metastatic breast cancer

Question 10

17a-alkylate testosterone

Types and application

Answer 10

Orally effective

Methyltestosterone, fluoxymesterone

Question 11

17a-alkylated testosterone

Methyltestosterone, fluoxymesterone

Indications

Answer 11

Hypogonadism and metastatic breast cancer

Question 12

17a-alkylated testosterone

Methyltestosterone, fluoxymesterone

Risk

Answer 12

High abuse potential for anabolic activity

Question 13

17a-alkylated testosterone

Methyltestosterone, fluoxymesterone

Contraindications

Answer 13

Male breast cancer

Prostate cancer

Pregnancy

Question 14

17a-alkylated testosterone

Methyltestosterone, fluoxymesterone

ADR

Answer 14

Cholestatic hepatitis

HIGHEST RISK OF HEPATOTOXICITY

Liver cancer

Bleeding (dec clotting factors)

Question 15

Contraindications for all testosterone analogs

Answer 15

Prostate cancer

Male breast cancer

Pregnancy

Question 16

ADR for all testosterone analogs

Answer 16

Salt and water retention (hypertension)

GREATEST RISK OF JAUNDICE WITH 17A-ALKYLATED TESTOSTERONE METHYLTESTOSTERONE AND FLUOXYMESTERONE

Question 17

Danazol

MOA

Answer 17

Depresses preovulatory surge in output of FSH and LH

Reduces ovarian estrogen and progesterone production

Suppresses FSH and LH surge=>anovulation

Question 18

Danazol

Uses

Answer 18

Endometriosis

Question 19

Danazol

ADR

Answer 19

Weight gain

Acne

Question 20

Danazol

Contraindications

Answer 20

Pregnancy

Breast feeding

Question 21

Stanazolol

MOA

Answer 21

Inc mRNA levels and protein levels of C1, INH, and C4

Question 22

Stanazolol

Use

Answer 22

Hereditary angioedema

Question 23

Stanazolol

ADR

Answer 23

Hepatic toxicity

Question 24

Stanazolol

Contraindications

Answer 24

Pregnancy

Male breast or prostate cancer

Female breast cancer with hypercalcemia

Question 25

Oxandrolone MOA

Answer 25

High anabolic to androgenic ratio

Question 26

Oxandrolone Use

Answer 26

For weight gain in pts who have undergone extensive surgery or have had severe trauma or long-term corticosteroid therapy and not gained weight

Question 27

Antiandrogens

Answer 27

Finasteride and dutasteride

Question 28

Antiandrogens Finasteride and dutasteride MOA

Answer 28

Reduce DHT. Finasteride: competitive inhibitor of type 2 5a-reductase Dutasteride: both types 1 and 2

Question 29

Antiandrogens Finasteride and dutasteride Use

Answer 29

BPH (may take 6 mos)

Question 30

Antiandrogens Finasteride and dutasteride Combination

Answer 30

Combine with a1-adrenergic receptor inhibitors (tamsulosin and alfuzosin) to dec smooth mm tone and relieve bladder outlet obstruction

Question 31

Antiandrogens Finasteride and dutasteride ADR

Answer 31

Lowers PSA levels by 50% Gynecomastia

Question 32

Leuprolide MOA

Answer 32

GnRH agonist Down regulates LH and FSH Dec circulating testosterone

Question 33

Leuprolide Use

Answer 33

Prostatic cancer Endometriosis

Question 34

Flutamide Use

Answer 34

Prostatic cancer (oral) Acne (topical)

Question 35

Flutamide ADR

Answer 35

Elevated liver function tests