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D&T3 Exam 1 > Uterus, Fallopian Tubes-Carpenter > Flashcards

Uterus, Fallopian Tubes-Carpenter Flashcards

(78 cards)

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1
Q

Carcinosarcoma

Define

A

Endometrial adenocarcinoma and ass malignant stromal component

Highly malignant

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2
Q

Leiomyosarcoma

A

Arise de novo from myometrium

Numerous genetic alterations with complex karyotypes and chromosomal abnormalities

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3
Q

Leiomyosarcoma

Morphology

A

Bulky fleshy mass within wall

Grows as polypoid mass

May just look like large leiomyoma

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4
Q

Endometrial adenocarcinoma

Type 1

Behavior

A

Indolent tumor

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5
Q

Adenomyosis

Sx

A

Similar to endometriosis

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6
Q

Endometriosis

In ovary

Histology

A

See endometrial glands and stroma along with hemosiderin-laden macrophages

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7
Q

Endometriosis

Metaplastic theory

A

May arise directly from coelemic

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8
Q

Leiomyomas

Microscopic

A

Whirled bundles of bland muscle with low mitotic count

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9
Q

Acute Endometritis

Diagnosis

A

Microabscesses seen along with destructions of glandular epithelium

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10
Q

Endometrial Adenocarcinoma

Histology

A

Malignant glands invading into the wall and mymetrium

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11
Q

Chronic Endometritis

Causes

A

Chronic PID

Postpartum/postabortion

Intrauterine contraceptive devices

Pts with TB

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12
Q

Endometrial adenocarcinoma

Type 2

Precursor

A

Serous endometrial intraepithelial carcinoma

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13
Q

Endometriosis

Regurgitation theory

A

Get retrograde menses

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14
Q

Inadequate Luteal Phase

Endometrial biopsy

A

Shows secretory endometrium that lags behind expected changes

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15
Q

Leiomyosarcoma

Microscopic

A

Inc mitotic rate

> 10 mitosis per 10/hpf

Cytologic atypia

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16
Q

Suppurative salpingitis

Ass

A

Ass with Gonococcus

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17
Q

Endometrial Polyps

Types

A
  1. Contains functional endometrium

2. Contains cystic, hyperplastic epithelium

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18
Q

Tubal Endometriosis

Histology

A

Glands and stroma

Normal tubal epithelium

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19
Q

Endometrial adenocarcinoma

Type 2

Behavior

A

Aggressive

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20
Q

Endometriosis

Morphology

A

Little powder burn marks

Responds to hormonal influences and may bleed

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21
Q

Endometriosis

Define

A

Presence of endometrial glands and stroma in abnormal locations outside the uterus

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22
Q

Dysfunctional uterine Bleeding (DUB)

Most commonly presents at

A

Menarche and perimenopause

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23
Q

Endometrial adenocarcinoma

Type 1

Clinical

A

Unopposed estrogen

Obesity

Hypertension

Diabetes

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24
Q

Endometrial adenocarcinoma

Type 2

Clinical

A

Thin

Atrophy

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25
Paratubal cysts
Small to prominent cysts hanging off Fallopian tubes Aka hydatid cys of morgagni Little clinical significance
26
Endometrial adenocarcinoma Type 1 Precursor
Hyperplasia
27
Leiomyomas Morphology
Well circumscribed firm white masses Can be large and distort uterus
28
Endometrial Polyps Sx
Can cause bleeding
29
Endometriosis Seen most commonly in...
Ovaries Uterine ligaments Rectovaginal septum Peritoneum
30
Endometriosis Can cause
Infertility Dysmenorrhea Pelvic pain
31
Endometrial Hyperplasia Ass conditions
Menopause Polycystic ovarian disease Excessive ovarian cortical function Prolonged estrogen replacement therapy
32
Endometriosis When does it occur?
Active reproductive time
33
Endometrial Adenocarcinoma Diagnosis
Not pap Do biopsy
34
Endometrial adenocarcinoma Type 1 Tumor characteristics
Endometriosis MC Forms polypoid mass Thickened endometrium
35
Endometrial Hyperplasia Genetic alterations
Inactivation of PTEN tumor suppressor (more sensitive to estrogen)
36
Endometrial Hyperplasia Atypical
Inc number of glands with complex structure and atypical nuclear features
37
Adenomyosis Histology
See Fock of endometrial glands and stroma within uterine wall Can form hemorrhagic nests within the wall
38
Endometrial Hyperplasia Types
Non-atypical Atypical (endometrial intraepithelial neoplasia)
39
Abnormal uterine bleeding Define
Excessive bleeding either between or during menses
40
Acute Endometritis Commonly seen in...
Patients after delivery or miscarriage Following instrumentation or due to retained products of conception
41
Chronic Endometritis Tx
Antibiotics
42
Endometrial adenocarcinoma Type 2 Tumor characteristics
Serous carcinoma- similar to ovarian
43
Dysfunctional uterine Bleeding (DUB) Results in...
Excessive and prolonged estrogen stimulation without development of progesterone phase
44
Fallopian Tube adenocarcinoma
Rare tumor Poor prognosis
45
Dysfunctional uterine Bleeding (DUB) Common causes
Endocrine disorders Ovarian disorders Systemic disorders
46
Endometrial adenocarcinoma Type 2 Genetic alterations
TP53
47
Inadequate Luteal Phase Define
Corpus lute up does not function properly Puts out inadequate amounts of progesterone Results in irregular cycles
48
Chronic Endometritis Histology
Plasma cells in endometrium
49
Inadequate Luteal Phase Presentation
Presents with infertility See either bleeding or amenorrhea
50
Fallopian tubes Infection
Suppurative salpingitis
51
Endometrial Polyps Histology
Multiple dilated endometrial glands Fibrous stroma
52
MC common invasive carcinoma of female genital tract
Endometrial carcinoma
53
Leiomyomas Clinical course
Can be asymptomatic Can be ass with abnormal bleeding, urinary frequency, pain, impaired fertility Rare malignancy
54
Endometrial Hyperplasia Cause
Prolonged estrogen stimulation (unopposed estrogen)
55
Carcinosarcoma Stromal component
Muscle, osteoporosis cartilage
56
Endometrial Hyperplasia Non-atypical
Inc number of simple dilated glands
57
Endometriosis Lymphvascular theory
May spread through pelvic vessels
58
Endometrial adenocarcinoma Type 2
Age 65-75
59
Abnormal uterine bleeding What to rule out
Endometrial hyperplasia and cancer
60
Endometrial adenocarcinoma Type 1 Genetic alterations
PTEN
61
Inadequate Luteal Phase Diagnosis
Perform biopsy after ovulation
62
Endometrial Hyperplasia Can cause
Excessive uterine bleeding
63
Leiomyosarcoma Characteristics
Peak 40-60yrs Strong tendency to recur Can spread to lungs, bone, brain
64
Menstrual Cycle Secretory
From time of ovulation to menses No mitoses Inc gland complexity Basal vacuolation=ovulation Inc secretion in glandular lumen
65
Endometrial Adenocarcinoma Clinical course
Present as bleeding, can see thickened endometrial lining on ultrasound Can be asymptomatic
66
Endometrial adenocarcinoma Type 1
MC Age 55-65
67
Endometrial Hyperplasia Atypical (endometrial intraepithelial neoplasia)
Inc glands with more crowding, enlargement, nuclear atypia Significant risk for progressing to adenocarcinoma Generally hysterectomy is performed
68
Leiomyomas
Benign Called fibroids 75% of women
69
Endometriosis In ovary Common presentation
Large cyst filled with brown material (called chocolate cyst or endometrioma)
70
Leiomyomas Common alteration
40% have simple chromosomal abnormality with normal karyotype Each tumor is unique clonal neoplasm
71
Fallopian tubes Benign lesions
Endometriosis
72
Endometrial Polyps Define
Common polyploid mass that occurs in endometrium Benign
73
Endometrial Adenocarcinoma Cross section
Thickened endometrium and invasion into the wall
74
Endometrial Hyperplasia Non-atypical
See inc gland to stromal ratio Can see cyst formation Rarely progresses to carcinoma Generally treated medically
75
Menstrual Cycle Proliferative
Time from end of menses until ovulation Glandular mitoses Estrogen
76
Dysfunctional uterine Bleeding (DUB) MC cause
Anovulatory cycles
77
Endometrial adenocarcinoma Morphology
Exophytic tumor protruding from and filling endometrial cavity
78
Endometriosis Histology
Collection of endometrial glands and stroma

D&T3 Exam 1 (19 decks)

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