Anemia

Question 1

Identify function of erythropoietin – what does it do, where is it produced & what stimulates its production

Answer 1

What:

Where:

How:

Question 2

Identify the laboratory test that provides an index of the erythropoietic action of the bone marrow

Question 3

Differentiate between adult and fetal hgb

Answer 3

Adult

Fetal

Question 4

Define anemia and associated values

Question 5

A megaloblastic anemia caused by gastritis with decreased production of intrinsic factor; accompanied by neurologic changes:

Answer 5

B-12

Question 6

A megaloblastic anemia associated with malnutrition, for example, in elderly people or people with alcoholism; not accompanied by neurologic changes:

Answer 6

Folic Acid Deficiency

Question 7

A cause of acute anemia with risk of hypovolemic shock; cells are of normal size and color:

Answer 7

Hemorrhagic anemia

Question 8

Accompanies gastric irritation associated with chronic aspirin use for control of arthritis pain:

Answer 8

Iron deficiency

Question 9

End-stage renal failure, AIDS, or cancer are most likely causes of:

Answer 9

Chronic disease anemia

Question 10

RBCs are injured and destroyed, for example by transfusion reactions, toxins, venoms, malaria, or by mechanical injury with burns or heart valve defects; RBCs are normal size and color:

Answer 10

Hemolytic

Question 11

Signs and symptoms include increased risk of bleeding, infections, and fatigue:

Answer 11

Aplastic

Question 12

Hereditary anemia affecting blacks; hemoglobin HbS causes abnormally shaped RBCs, which lead to hypoxia:

Answer 12

Sickle Cell

Question 13

Hereditary anemia in various racial and ethnic groups; errors occur in synthesis of hemoglobin chains; children with disorder may have severe growth retardation:

Answer 13

thalasemmia

Question 14

An autosomal dominant disorder in which RBCs form tight spheres that are easily destroyed in vessels of the spleen; may be treated by splenectomy:

Answer 14

spherocytosis

Question 15

Macrocytic-normochromic eteology

Answer 15

Vitamin B-12

Folic acid

Question 16

Microcytic-hypochromic eteology

Answer 16

Iron deficiency

Decreased heme synthesis

Question 17

Discuss the “common or classic “ clinical manifestations of anemia and the pathogenesis behind them

Question 18

Discuss clinical manifestations seen with the hemolytic anemias

Question 19

Discuss clinical manifestations seen with the aplastic anemias

Question 20

B-12 deficiency:

Etiology

Question 21

B-12 deficiency:

pathogenesis

Question 22

B-12 deficiency:

Manifestations

Question 23

Folic acid deficiency:

eteology

Question 24

Folic acid deficiency:

pathogenesis

Question 25

Folic acid deficiency:

Manifestations

Question 26

Identify the major causes of hemolytic anemias

Question 27

Identify the factors that can precipitate sickle cell crisis

Question 28

Identify the hemolysis seen in G6PD anemia

Question 29

Define polycythemia

Question 30

What is relative polycythemia?

Give examples

Question 31

What is Primary polycythemia?

Give examples

Question 32

What is seconday polycythemia?

Give examples

Question 33

Discuss the pathogenesis behind the clinical manifestations seen in primary polycythemia (polycythemia vera)