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Flashcards in Anemia drugs Deck (37):
1

Iron Preparation drugs

For microcytic anemia
Ferrous sulfate
Ferrous gluconate
Ferrous Fumarate
Iron dextran
iron sucrose
Sodium-ferric gluconate

2

Ferrous sulfate, ferrous gluconate, ferrous fumarate description

Oral iron therapy

3

Ferrous sulfate, ferrous gluconate, ferrous fumarate pharmacodynamics

works just as good as parenteral if absorption is normal

4

Ferrous sulfate, ferrous gluconate, ferrous fumarate indication

iron deficient anemia

5

Ferrous sulfate, ferrous gluconate, ferrous fumarate adverse

GI: Constipation, dark stools, cramps, vomiting, diarrhea

6

Iron dextran, iron sucrose, Sodium-ferric gluconate description

parenteral iron therapy

7

Iron dextran, iron sucrose, sodium-ferric gluconate pharmacodynamics

Toxicity is very rare; mostly occurs in young children after accidental ingestion

8

Iron dextran, iron sucrose, sodium-ferric gluconate indication

Patients who do not tolerate or absorb iron well

Extensive anemia that cannot be maintained on oral iron alone

9

Iron dextran, iron sucrose, sodium-ferric gluconate adverse

Acute iron toxicity -> necrotizing gastroenteritis with vomiting, abdominal pain, bloody diarrhea (-> possibly shock, metabolic acidosis, coma and death)
Treat-> deferoxamine

10

Iron chelator drugs

Deferoxamine
Deferasirox

11

Iron chelator description

Phlebotomy-for chronic iron overload without anemia

12

Iron chelator pharmacodynamics

Binds absorbed iron and promotes excretion

13

Iron chelator indication

Chronic iron toxicity:
Hemochromatosis or multiple transfusions

14

Vitamin B12 aka Cyanocobalamin
Hydroxycobalamin
Description

For macrocytic anemia
Parenteral (huge body stores take a long time to deplete)

15

Vitamin B12, cyanocobalamin, hydroxycobalamin pharmacodynamics

Two reactions:
homocysteine -> methionine
methyl-malonyl -> succinyl

16

Vitamin B12, cyanocobalamin, hydroxycobalamin indication

Malabsorption of Vit B12 (loss of IF,etc)
Can be partly correct with folic acid

17

Vitamin B12, cyanocobalamin, hydroxycobalamin adverse

Deficiency of cobalamin can cause neurologic abnormalities due to increased homocysteine

18

Folic acid description

macrocytic anemia
Deficiency is a lot more common than B12 but can be easily corrected

19

Folic acid pharmacodynamics

required for purine synthesis
Need B12 to for THF -> folate trap

20

Folic acid indication

Folate deficiency (1-6 months to develop) can cause congenital malformation and vascular disease
Drug induced: MTX, trimethoprim, pyrimethamine (inhibit DHF reductase)

21

Folic acid adverse

Masking of neurologic deficits in B12 deficiency

22

Erythropoietin description

stimulates erythroid proliferation (JAK/STAT)

23

Erythropoietin pharmacodynamics

produced in the kidney in response to hypoxia

24

Erythropoietin indication

Anemia with renal disease (can't produce endogenous EPO -> best responders)

25

Darbepoetin description

3x longer acting than EPO
-Two CHO chains

26

Darbepoetin indications

chronic anemia with renal failure
Myelosuppressive chemotherapy

27

Erythropoietin and Darbepoetin adverse

Hyperviscosity -> HTN and thrombosis

28

Filgrastim and Sargramostim description

Myeloid growth factors with JAK/STAT receptors

29

FIlgrastim and Sargramostim pharmacodynamics

proliferation and differentiation of PMN's

30

Filgrastim and Sargramostim indication

Neutropenia (1 or 2 degree)
Chemotherapy

31

IL-11 description

Megakaryocyte growth factor

32

IL-11 pharmacodynamics

Increases platelets

33

IL-11 Indications

Hx of thromboycytopenia with chemo; decreases need for platelet transfusion

34

Hydroxyurea description

Relieves painful course of sickle cell disease

35

Hydroxyurea pharmacodynamics

Increases HbF concentration

36

Hydroxyurea indication

Sickle cell anemia

37

Hydroxyurea Adverse

BM suppression
Cutaneous vasculitis