Drugs used to treat bleeding Flashcards Preview

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Flashcards in Drugs used to treat bleeding Deck (14)
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1
Q

Aminocaproic acid class

A

t-PA inhibitor

2
Q

Aminocaproic acid description

A

synthetic inhibitor of fibrinolysis

3
Q

Aminocaproic acid mechanism

A

inhibits activation of plasminogen

4
Q

Aminocaproic acid indication

A

Hemophilia
Bleeding from fibrinolytic therapy
Aneurysm bleeding
Post-surgical GI bleed

5
Q

Aminocaproic acid adverse/contraindications

A
Intravascular thrombosis
HTN, myopathy
Abdominal discomfort, diarrhea
Nasal stuffiness
****DO NOT use in DIC or upper GI bleeding****
6
Q

Protamine sulfate class

A

antidote

7
Q

Protamine sulfate description

A

chemical antagonist binds heparin rendering it inactive (lots of arginine gives it a strong +ve charge)

8
Q

Protamine sulfate indication

A
Heparin toxicity (UFH)
Not effect against fondaparinux
9
Q

Protamine sulfate adverse

A

Coagulation if no heparin

Hypersensitivity -> dyspnea, flushing, bradycardia, hypotension

10
Q

Vitamin K class

A

Antidote

11
Q

Vitamin K description

A

Carboxylates clotting factors
Response is complete in 24 hrs, onset in 6
FFP used for immediate hemostasis

12
Q

Vitamin K Indication

A

Stops bleeding induced by oral anti-coagulation (Warfarin)

Hypoprothrominemia in babies

13
Q

Plasma fractions description

A

replaces coagulation factors that are dificent in genetic disorders

14
Q

Plasma fractions indication

A

Hemophilia A -> PF-8

Christmas disease -> PF-9