Drugs used to treat bleeding Flashcards Preview

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Flashcards in Drugs used to treat bleeding Deck (14):
1

Aminocaproic acid class

t-PA inhibitor

2

Aminocaproic acid description

synthetic inhibitor of fibrinolysis

3

Aminocaproic acid mechanism

inhibits activation of plasminogen

4

Aminocaproic acid indication

Hemophilia
Bleeding from fibrinolytic therapy
Aneurysm bleeding
Post-surgical GI bleed

5

Aminocaproic acid adverse/contraindications

Intravascular thrombosis
HTN, myopathy
Abdominal discomfort, diarrhea
Nasal stuffiness
****DO NOT use in DIC or upper GI bleeding****

6

Protamine sulfate class

antidote

7

Protamine sulfate description

chemical antagonist binds heparin rendering it inactive (lots of arginine gives it a strong +ve charge)

8

Protamine sulfate indication

Heparin toxicity (UFH)
Not effect against fondaparinux

9

Protamine sulfate adverse

Coagulation if no heparin
Hypersensitivity -> dyspnea, flushing, bradycardia, hypotension

10

Vitamin K class

Antidote

11

Vitamin K description

Carboxylates clotting factors
Response is complete in 24 hrs, onset in 6
FFP used for immediate hemostasis

12

Vitamin K Indication

Stops bleeding induced by oral anti-coagulation (Warfarin)
Hypoprothrominemia in babies

13

Plasma fractions description

replaces coagulation factors that are dificent in genetic disorders

14

Plasma fractions indication

Hemophilia A -> PF-8
Christmas disease -> PF-9