Anesthesia Flashcards
(34 cards)
Inhaled induction agents
Cause respiratory depression, most have myocardial depression, increased cerebral flow, and decreased renal blood flow
MAC
minimum alveolar concentration. Smallest concentration that causes 50% of people to not move with incision.
Smaller MAC = more lipid soluble-> more potent less water soluble slower the speed
Speed of induction inversely proportional to solubility. NO is fastest but, has low lipid solubility, has high MAC, low potency
Sevoflurane
MC used. Fast, less laryngospasm. Less pungent. Good for mask induction
Desflurane
Most rapid onset/offset. Pungent, not used for induction, reserved for maintenance
Nitrous oxide NO2
minimal myocardial depression. Always used with sevoflurane or desflurane. Do not use with SBO or PTX
- Causes tremors
Halothane
highest degree of cardiac depression and arrhythmias. Least pungent→ Good for kids
Volatile anesthetic hepatitis
fever, eosinophilia, jaundice, Increase LFT
Isoflurane
Good for neurosurgery, (lowers brain o2 consumption, no increase in ICP). Pungent, not used for induction
Enflurane
can cause seizures
MCC of intra-op bradycardia
inhaled anesthetic. Tx: atropine
Inhalation induction agents
Nitrous oxide, halothane, sevoflurane, isoflurane, enflurane
Intravenous induction agents
Propofol, ketamine, etomidate
Propofol
-Not an analgesic
-Metabolized in liver
-Provides bronchodilation #1 choice to patients with asthma or airway disease
- Best one to prevent post op nausea and vomiting
- Side effects: respiratory depression, hypotension
- Propofol infusion syndrome – causes bradycardia (must have this for dx), and METABOLIC ACIDOSIS, with hyperkalemia, renal failure, rhabdomyolysis, hepatomegaly, CHF. increased risk in kids
- Can measure CPK and lactate levels daily to catch early
- Treatment: stop propofol and start hemodialysis
- Propofol contraindicated in egg allergy, pregnant, Parkinson’s
Dexmedetomidine (Precedex)
alpha 2 receptor agonist. Does not cause respiratory depression. Can decrease BP
-Anesthesia and analgesia
-sedation agent for intubated patients; not an induction agent
-Not recommended for more than 24 hours
Ketamine
-Amnesia, analgesia
-No respiratory depression, good for children, safe with head injury
– Ischemic heart disease: can cause HTN and tachycardia leading to increased myocardial oxygen consumption
-Historically contraindicated in patients with elevated ICP and intraocular P; however no longer absolute contraindications
-
Etomidate
Fewest cardiac side effects
Not an analgesic
SE: adrenal insufficiency/ supression, myoclonus, stevens-johnson syndrome, trismus
…post op fever, hypotension, hypokalemia
Rapid sequence intubation
Pre-oxygenate, etomidate, succinylcholine, cricoid pressure
1st/last muscles to go down/recover
Diaphragm: last muscle to go down, 1st muscle to recover from paralytics
Neck & face muscles: 1st to go down, last to recover
Succinylcholine
*Only depolarizing agent & only one that causes fasciculations
-Metabolized by plasma pseudocholinesterase.
Atypical pseudocholinesterase causes prolonged paralysis with succinylcholine (Asians). Not reversible. Have to wait till it wears off.
-Open-angle glaucoma can become closed-angle glaucoma
Contraindicated in:
- neurologic diseases (spinal cord injury, neuromuscular disorders) Have upregulation of Ach receptors: hyperkalemia
- In head injury: increases ICP
-Severe burns, acute renal failure
Malignant hyperthermia
Malignant hyperthermia
Defect in calcium metabolism
Calcium released from sarcoplasmic reticulum causes muscle excitation- contraction syndrome (ryanodine receptor defect)
SE: 1st= increase end-tidal CO2, then fever, tachycardia, rigidity, acidosis, hyperkalemia, rhabdomyolysis
Tx= dantrolene (10 mg/kg) inhibits Ca release and decouples excitation complex; cooling blankets, HCO3, glucose
Non-depolarizing agents
inhibit neuromuscular junction by competing with acetylcholine
Cis-atracurium, rocuronium, vecuronium, pancuronium
Cisatracurium (Nimbex) – Hoffman elimination. Use this if patient has liver or kidney disease!!!!
Pancuronium – metabolized in kidney. Slow and long acting. MC SE is tachycardia. DON’T USE IN ANY ARRYTHMIA or CAD.
Rocuronium – 1 mg/kg for induction. Fastest acting. metabolized in liver. Little effect on blood pressure. Short half life
Vecuronium – Metabolized in kidney. Short half life
Reversal of non-depolarizing agent – Sugammadex is best. Also can use Neostigmine or edrophonium to block Ach-esterases. Add atropine or glycopyrrolate to counteract Ach overdose
Local anesthetics
Amides - have 2 I’s. Lidocaine, bupivacaine, mepivacaine. Rarely cause allergic reaction
Esters - tetracaine, procaine, cocaine. Has higher risk of allergic reactions due to PABA
Benzocaine: can cause methemoglobinemia
Narcotics (opioids)
Narcotics (opioids) – causes respiratory depression, NO cardiac affects. Morphine causes hypotension from histamine release
Act on mu receptor in CNS
Liver metabolism and kidney excretion
Avoid morphine and codeine in renal injury
Dilaudid is metabolized in liver but only small amount excreted in kidney. OK to use in AKI
Fentanyl and methadone = safest to use in ESRD
Demerol - meperidine
- SE→ Tremors, fasciculations, coma, seizures, avoid in patients with renal failure
- Avoid with MAOI, can cause hyperpyrexic coma→ serotonin release syndrome
- No histamine release
Fentanyl – no histamine release. Can give if pt has morphine allergy
Sufentinel – Most potent
Benzos + opioid has synergistic effects
Benzos
Metabolized in liver
Binds GABA
-Versed (midazolam): short acting; crosses placenta
-Valium(diazepam) & Ativan (lorazepam): long acting
Overdose= flumazenil