ANS Flashcards
Botulinum toxin
Inhibits release of acetylcholine from presynaptic neuron by inhibiting calcium channel
Which type of botulinum toxin is used as drugs
Type A toxin»»type B
Type A botulinum toxin e.g.
Onabotulinum toxin A(botox),
Abobotulinum toxin A(dysport),
Incobotulinum toxin A
Antagonist of Nn receptors
Ganglionic blockers
E.g- hexamethoneum
Trimethaphan
Nm receptors antagonist
Non depolarising muscle relaxant (NDMR)
E.g - tubo curare
Atra curium
Ve curonium
Predominant muscarinic receptor in brain
M1
Drug for alzheimer and why
Cholinergic drugs—> inc. Ach —-> acts on hippocampus
Ach–> inc. memory and cognition
Cholinergic or anti cholinergic drugs in parkinson’s disease,why
Anti cholinergic drugs.
Ach —> acts on basal ganglia –>
dec. Dopamine
M1 receptor agonist
OXOTREMORINE (inc. HCl)
M1 receptor antagonist
PIREN ZEPINE,
TELEN ZEPINE,
dec. HCl , therefore given in PEPTIC ULCER
Which muscarinic receptor antagonist are given in PEPTIC ULCER and why
M1 receptor antagonist,
PIREN ZEPINE
TELEN ZEPINE,
dec. HCl
M2 receptor is located in
Heart
M2 receptor agonist
METH CHOLINE
M3 receptor function
Vasodilation - blood vessels
Contraction -smooth muscle
M3 receptor agonist
BETHAN ECOL
inc. smooth muscle contraction
M3 receptor antagonist
SOLE FENA CIN,
DARE FENA CIN,
relaxes smooth muscle
Direct acting cholinergic drugs - esters e.g.
chol in all
A- Acetylcholine
B- BETHANE CHOL
C- CARBA CHOL
M- METHA CHOLINE
Specific Aplha 1 agonist
PHENYL EPHRINE
Specific Aplha 2 agonist
COLNIDINE
Specific Aplha 1 antagonist
PRA ZO SIN
Specific Aplha 2 antagonist
YO HIM BINE
Non specific Alpha agonist
EPINEPHRINE,
NOR EPINEPHRINE
Non specific Alpha antagonist
PHENOXY BENZAMINE,
PHENYO LAMINE
Specific beta 1 agonist
DO BUTAMINE