ANS Flashcards by Angelica Pascual

Biosynthesis of cathecolamines

Location:

Sympathetic post ganglion
Adrenal medulla
CNS

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Enzyme required to convert tyrosine to L-DOPA

Tyrosine hydroxylase

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Enzyme needed to covert L-DOPA to Dopamine

L-DOPA decarboxylase

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Enzyme needed to convert dopamine to NE

Dopamine-B-hydroxylase

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Enzyme needed to convert NE to epinephrine

Phenylethanolamine-N-methytransferase

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Responsible for the metabolism of catecholamines

MAOs and COMTs

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Responsible for the metabolism of Acetylcholine

Acetylcholinestrases

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Inhibits Formation of L-DOPA

Methyrosine

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Dopamine storage inhibitor

Reserpine

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Releasers of catecholamines

Tyramine
Amphetamine
Ephedrine
ANGF
a-latro toxin

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Inhibits Release of catecholamines

Guanethedine
Guanedrel
Bretylium

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Reuptake inhibitors of catecholamines

TCAs
Cocaine
Robexetine

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B1 > A1

Choices:
A. Epi
B. NE
C. Dopamine

B. NE

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B1 = B2&raquo_space; A1

Choices:
A. Epi
B. NE
C. Dopamine

A. Epi

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D1 > B1 > A1

Choices:
A. Epi
B. NE
C. Dopamine

C. Dopa

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Metabolism of Epi and NE’s product

Vanillylmandelic acid or 3-methoxy-4-OH-madelic acid

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Metabolism of Dopamine’s product

Homovanillic acid

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1st line tx for anaphylactic shock

Epinephrine

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1st line tx for septic shock

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aka adrenaline

Epinephrine

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Aka levarterenol

Norepinephrine/ Noradrenaline

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Mgt of septic and cardiogenic shock
Mgt of AHF
Diuresis

Dopamine

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Adverse effect during a1 overstimulation

Digital necrosis

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Adverse effect during B1 overstimulation

Ventricular tachyarrhythmia

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aka isoprenaline

Isoproterenol

1st line tx for cardiogenic shock

Dobutamine

2 examples of SABA or short acting B agonist

Albuterol and Terbutaline

aka albuterol

Salbutamol

2 examples of Tocolytic B1 agonists

Ritodrine and isoxsuprine

Mgt of symptomatic bradycardia

Terbutaline

Selective a1 agonists ``` P P M T O N ```

``` Phenylephrine Propyhexedrine Methoxamine Tetrahydrozoline Oxymetazoline Naphazoline ```

Selective a2 agonists C M G G

Clonidine Methyldopa Guanabenz Guanfacine

Only 4 safe antihypertensive drugs for pregant

Mommy Nife hates labor (MNHL) Methyldopa Nifedipine Hydralazine Labetalol

Active metabolite of Methyldopa

a-methyl norepinephrine

Selective D1 agonist used in the mgt of HTN crisis

Fenoldopam

Centrally acting sympa drugs ``` P P P A M ```

``` Phentermine Phenmeyrazine PPA- phenylpropanolamine Amphetamine Methylphenidate ```

1st line tx in mgt of ADHD

Methylphenidate

Centrally acting sympa drugs used in the mgt of anorexia PPP

Phentermine Phenmetrazine PPA- Phenylpropanolamine

Centrally acting sympa drugs used in the mgt of narcolepsy AP

Amphetamine and phentermine

Non selective a antagonist

Phenoxybenzamine | Phentolamine

a2 atagonists RY

Rauwolscine | Yohimbine

Non selective Beta blockers "NSTP"

Nadolol Sotalol Timolol Propanolol

B1 blockers aka cardioselective beta blockers CBBEAAM "c-beam"

``` Celiprolol Bisoprolol Betaxolol Esmolol Acebutolol Atenolol Metoprolol ```

Beta blockers w/ ISA (intrinsic sympathomimetic activity) Celi-CAPP-Lab

``` Celiprolol Carteolol Acebutalol Pindolol Penbutol Labetalol ```

Beta blockers with membrane stabilizing effect aka local anesthetic effect Prop(esor) Met Pin (nag) Ace sa Lab

``` Propanolol Metoprolol Pindolol Acebutalol Labetalol ```

B blockers with a1 blocking effect i Lab Carbs

Labetalol | Carvedilol

Most Cardioselective b blocker

Nebivolol

Biosynthesis of Ach Location

All pre-ganglionic Cholinergic, post ganglion CNS Somatic nerve

Enzyme needed to produce Ach from choline and acetyl coa

Choline acetyltransferase

Inhibitor of Active uptake of choline

Hemicholinium

Inhibits storage of Ach

Vesamicol

Releaser of Ach

a-latro toxin

Release inhibitor of ach

Botulinum toxin

Location of Nm receptor

Neuromuscular end plates

Location of Nn

Ganglion

M selective choline ester (direct acting parasympa drug)

Betanechol

Non selective choline ester (direct acting parasympa drug) A M C

Ach Metacholine Carbachol

Non selective alkaloid (direct acting parasympa drug)

Arecoline

N selective alkaloid (direct acting parasympa drug)

Nicotine Varenicline Lobeline

M selective alkaloid (direct acting parasympa drug)

Muscarine and Pilocarpine

Aka eserine

Physostigmine

Aka ambenonium

Pyridostigmine

Used in dx of myasthenia gravis

Edrophonium

Used in tx of myasthenia gravis

Pyridostigmine

Tx for atropine poisoning

Pilocarpine

Tx for sjorogen's syndrome

Pilocarpine

Tx for organophosphate poisoning

Pralidoxime or Diacetylmonoxime (DAM) -aka Enzyme regenerators

Tx for AE of parasympa drugs

Atropine or enzyme regenerators like DAM and pralidoxime

M1 blockers

Pirenzipine | Telenzepine

M3 blockers G H C D

Glycopyrrolate Hyoscine N butyl Bromide Clidinium Dicycloverine/Dicyclomine

Ganglionic/ Nn blockers

Hexamethonium Mecamylamine Trimethaphan

Depolarizing Non competetive Neuromuscular/ Nm blocker

Succinylcholine

Non Depolarizing - competetive Neuromuscular/ Nm blocker (ISOQUINOLONES)

Atracurium Mivacurium Cisatracurium Tubocurarine

Non Depolarizing - competetive Neuromuscular/ Nm blocker (STEROIDS)

Rocuronium Pancuronium Vecuronium