ANS

Question 1

A agonist

Answer 1

Phenylephrine
a1 > a2
Clonidine
a2 > a1

Question 2

Mixed a and B agonist

Answer 2

Norepinephrine
a1 = a2, B1
Epinephrine
a1=a2 b1=b2

Question 3

B Agonist

Answer 3

Dobutamine . B1>B2»»a
Isoproterenol B1=B2&raquo_space;»a
Terbutaline/albuterol B2»B1»»a

Question 4

Dopamine Agonist

Answer 4

Dopamine . D1=D2»B

Fenoldopam D1»D2

Question 5

Termination of Catecholamine

Answer 5

Reuptake,
MAO,
COMT,
Lungs

Question 6

Termination of non-catecholamine

Answer 6

MAO
Urinary Excretion (unchanged)

Question 7

Sympathomimetic

Answer 7

Beta-phenylethylamine derivatives
Amine (NH2) side chain
Hydroxy group on 3,4 Cs of benzene ring –> catechol

Question 8

Synthetic non-catecholamine

Answer 8

Indirect Acting:
Ephedrine, mephentermine, amphetamines

Direct Acting
phenylephrine, methoxamine

Question 9

Epinephrine

Answer 9

Most potent a activator
SQ or IV
Very poor lipid soluble
Onset: 1-2 min, SQ 5-10
Duration: 5-10 min

Question 10

Epinephrine Indications

Answer 10

bronchial asthma, 
acute allergic reaction
cardiac arrest, asystole
Electromechanical dissociation
V-fib
Infusion to > myocardial contractility

Question 11

Epinephrine Dosing

Answer 11

10 mcg/kg IV Bolus
2-8 mcg/kg
1-2 mcg/min IV = B2
4-5 mcg/min IV = B1
10-20 mcg/min IV = a and;B

Question 12

CV Effects of Epinephrine

Answer 12

a1- vasoconstriction: >BP/CVP, > cardiac work (>Preload)
a2 negative feedback: contractility/ HR/ CO = >BP
B2 Peripheral vasodilation: SBP, < DBP, MAP same

Question 13

Epinephrine: vasoconstriction of arterioles

Answer 13

minimal
cerebral vasculature
Coronary vasculature
Pulmonary vasculature

Question 14

Epinephrine Eye Effects

Answer 14

a1 = mydriasis
a1/a2 > humoral outflow
B1 > production of humor
> IOP

Question 15

Epinephrine Resp Effects

Answer 15

B2: dilate bronchi smooth muscle, < release of histamine
a1: < mucosal secretion/ decongestion

Question 16

GI effects of Epinehrine

Answer 16

a2: < digestive secretions
a, B2: < peristalsis
a1: < splanchnic blood flow

Question 17

GU effects of Epi

Answer 17

a1: < renal blood flow, contraction of urethral sphincter, facilitate ejaculation
B1: > renin release
B2: bladder relaxation (

Question 18

Metabolic effects of Epi

Answer 18

B2: > liver glycogenolysis, > Insulin release
B3: > lipolysis
a2: (minor) < insulin release

Question 19

Norepinephrine

Answer 19

4-16 mcg/min
Effects: vasoconstriction (@skeletal, kidney, liver, cutaneous) = met acidosis, >SBP/DBP/MAP
Baroreceptors: will < HR, < resp

Question 20

Dopamine Doses

Answer 20

1-3 mcg/kg/min
  dopamine 1 receptor dominate
3-10 mcg/kg/min
       B1 dominate
>10mcg/kg/min
     a stimulation dominate

PIV dangerous-infiltrate
Less vasoconstriction then NE

Question 21

Dopamine effects

Answer 21

> contractility, renal blood flow, UO, GFR
NE release (not as useful w/ < catecholamine stores)
synergistic w/ dobutamine (CO)
inhibitory @ carotid body
IOP