Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Pharmacology > ANS Adrenergic > Flashcards

ANS Adrenergic Flashcards

(56 cards)

Start Studying
1
Q

acebutolol

A

Beta 1 selective receptor antagonists. Class II antiarrhythmic fast Na+ blocker.

TX. prohylaxis post-MI and supraventricular tachyarrhythmias. angina, HT,

less effect vasospasm, bronchospasm, uterus, metabolism.Safer in asthma, diabetes, peripheral vascular disease. ISA: intrinsic sympatomimetic activity as partial agonist with less bradycardia (-b1) and slight vaso/broncho dilation (-b2) and no change in lipids (-b2) adv. some sedation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Albuterol

A

Beta 2 agonist Tx asthma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Alpha 1 receptor activation effects

A

Gq (phospholipase C, Ip3, DAG, Ca+2) eye mydriasis: radial dilator contraction (no cycloplegia!) arterioles contraction veins contraction bladder trigone and sphincter contraction male sex organs vas deferens ejaculation liver glycogenolysis kidney DECREASED renin release

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Alpha 1 effects on HR and BP

A

arterioles contraction veins contraction Increase TPR and BP potential bradycardia reflex CO may decrease, offset by increase venous return NO-change in pulse pressure (systolic-diastolic) *phenylephrine and methoxamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Alpha 2 effects on HR and BP

A

prejunctional nerve terminals *DECREASE NE* platelets aggregation decreased CNS SANS prejunctional outflow used in mild to moderate HTN clonidine, methyldopa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Alpha 2 receptor activation effects

A

Gi (decrease adenylyl cyclase, cAMP) **prejunctional nerve terminals DECREASE NE release** platelets aggregation pancrease DECREASE insulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

amphetamines

A

indirect acting adrenergic receptor agonists releaser displace NE from mobile pool (neurojunction) psychostimulant do to central release of DA, NE, 5HT Tx. methyl phenidate in narcolepsy and ADHD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Alpha receptor antagonist

A

decrease TPR, mean BP potential reflex tachycardia, salt/water retention tx. HT, pheochromocytoma, BPH phentolamine, phenoxybenzamine prazosin, doxazosin, terazosin, tamsulosin yohimbine, mirtazapine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

atenolol

A

Beta 1 selective receptor antagonists

TX. angina, HTN, post-MI

adv. Blood lipids increases LDL and TGs, sexual dysfunction, cardiovascular depression. Caution (but safer) in asthma, vasospastic disorders, diabetics (decreases insulin secretion), pregnancy

No sedation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Baroreceptor reflex

A

Increased BP elicits baroreceptor discharge to cardiovascular center. Nn blockers to block reflex at ganglionic synapse Nm2 block reflex bradycardia HR (vagal tone) B1 block reflex tachycardia HR, contractile force and vasoconstriction.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Beta agonist effects on HR and BP

A

beta 1: SA node positive chronotropy AV node positive dromotropy atrial/ventricular muscle positive inotropy His-purkinje positive dromotrophy beta 2: blood vessel vasodilate (non-innervated) beta 2 decrease BP (decrease TPR) beta 1 increase HR (increase SV, CO, pulse pressure= systolic-diastolic) isoproterenol, dobutamine salmeterol, albuterol, terbutaline, ritodrine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Beta receptor antagonists

A

Beta 1 blockade: decreased HR, SV, CO, renin, aqueous humour production beta 2 blockade: may precipitate bronchospasm, vasospasm block glycogenolysism gluconeogenesis increase LDL and TGs Chronic use leads to receptor upregulation; therefor important to taper use to avoid rebound of endogenous amines. acebutolol, atenolol, metoprolol, pindolol, propranolol, timolol labetalol, carvedilol, sotalol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Beta1 receptor activation effects

A

Gs (increase adenylyl cyclase, cAMP) SA node positive chronotropy AV node positive dromotropy atrial/ventricular muscle positive inotropy His-purkinje positive dromotrophy kidney increased renin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Beta2 receptor activation effects

A

Gs (increase adenylyl cyclase, cAMP) mostly non-innervated blood vessels vasodilate uterus relaxation brochioles dilation skeletal glycogenolysis (tremor) liver glycogenolysis pancrease increase insulin (metabolize fat and gluconeogenesis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

carvedilol

A

combined alpha 1 and beta blocker

tx. CHF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Catechol-O-methyltransferase (COMT)

A

degrades NE at synapse

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Clonidine

A

alpha 2 agonists

  • decreases CNS SANS prejunctional outflow of NE
    • decrese TPR and HR

TX. mild to moderate HTN and opiate withdrawl

ADV. CNS depression, edema.

DI: TCAs decrease antiHTN effets

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Cocaine

A

indirect acting adrenergic receptor agonists reuptake inhibitor NE (neurojunction)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Closed Angle Glaucoma

A

Acute or Chronic increased introccular pressure due to blockage of cannal of schlemm Tx. SURGERY. cholinomimetics, carbonic anhydrase inhibitors, mannitol. C/I alpha 1 agonist (myadriasis further closing the angle cannal)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

dobutamine

A

B1>B2 agonist

TX. CHF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Dopamine

A

sympathomimetic. vasodilate renal, mesenteric, coronary vascular beds

Synthesized from Tyr hydroxylase metabolite: homovanillic acid

  • Dopamine will stimulate D1(Gs) at low dose,
  • beta 1 at medium dose alpha 1 at high dose

TX. CHF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

doxazosin

A

Alpha 1 selective receptor antagonist

  • decrease arteriolar, venous, sphincter resistance

TX. HTN, BPH (decrease urinary frequency and nocturia) [good effect on lipid profil]

ADV reflex tachycardia, first dose effect, orthostatic hypotension, urinary incontenence.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Ephedrine

Study These Flashcards
A

indirect acting adrenergic receptor agonists releaser displace NE from mobile pool (neurojunction) tx. cold medication

22
Q

Epinephrine

Study These Flashcards
A

Synthesized from Tyr from Dopa/NE by adrenal medula. metabolite: vanillylmandelic acid (VMA) mixed acting agonist low dose beta > alpha effects: b1: increased HR, SV, CO, pulsepressure. b2: decreased TPR, BP medium dose opposing alpha 1 effect of increased TRP, BP high dose effect similar to NE alpha > beta with potential reflex bradycardia. *alpha1 blocker to reverse HT in OD to eliminate vasatone and unmask beta 2 effects* Tx. cardiac arrest, adjunct to local anesthetic, hypotension, anaphylaxis, asthma

23
esmolol
**Class II antiarrhythmic** fast Na+ blocker. IV. TX. **_acute_ supraventricular tachyarrhythmias**
24
Fenoldopam
D1 agonist Tx severe hypertension at high dose D1, beta1, alpha1 agonist as dose increases
25
Glucagon receptors of the heart
Gs coupled glucagon receptors positive inotropic and chronotropic effects on the heart \*beta blockers in glucagon OD\*
26
Guanethidine
act directly on the granule of NE in perjunctional nerve, decreasing NE release
28
isoproterenol
B1=B2 agonist TX. bronchospasm, heart block, bradyarrythmias Adv. flushing, angina, arrhythmias
28
labetalol
combined alpha 1 and beta blocker tx. CHF
29
methoxamine
alpha 1 agonist paroxysmal atrial tachycardia through vagal reflex
30
methyldopa
alpha 2 agonists * decreases CNS SANS prejunctional outflow of NE * decrese TPR and HR TX. **mild to moderate HTN** (safe in **pregnancy)** ADV. CNS depression, edema, **positive coombs test.** DI: TCAs decrease antiHTN effets
31
metoprolol
Beta 1 selective receptor antagonists TX. angina, **HTN,** post-MI adv. some sedative and blood lipids increases LDL and TGs, sexual dysfunction, cardiovascular depression. Caution (but safer) in asthma, vasospastic disorders, diabetics (decreases insulin secretion)
33
Monoamine Oxidase (MAO)
inactivates NE in the prejunctional nerve terminal MAO-a: liver and anywhere metabolizes NE, 5HT, tyramine MAO-b: brain metabolizes DA
33
mirtazapine
Alpha 2 selective receptor antagonist tx. antidepressant
35
non-selective Adrenergic effects on receptors at varying doses
non selective adrenergics responses at low dose beta \> alpha at high dose alpha \> beta Dopamine will stimulate D1 at low dose, beta 1 at medium dose alpha 1 at high dose
36
Norepinephrine
Synthesized from Tyr from Dopa within nerve ending vessicles. stored as granules metabolite: vanillylmandelic acid (VMA) mixed acting agonist (alpha 1/2, beta1) increase TRP, BP, HR, SV, CO, increase pulse pressure=systolic-diastolic potential reflex bradycardia no effect Beta2 Tx. cardiac arrest, adjunct to local anesthetic, hypotension
37
Open angle glaucoma
chronic painless increased intraocular pressure due to decreased reabsorption of aqueous humour tx. beta blocker - timolol (decrease NE at ciliary epithelial tereby decreasing fluid formation) M3 agonist -pilocarpine (contract ciliary muscle to increase drainage) AchE Inhibitor - echothiophate
38
phenoxybenzamine
Alpha receptor noncompetitive antagonist (Vmax decreased, Km unchanged)
39
phentolamine
Alpha receptor competitive antagonist (Vmax same, Km increased)
40
phenylephrine
alpha 1 agonist nasal decongestant and opthalmic myadriasis (without cycloplegia)
41
pindolol
non selective beta receptor antagonists ISA: intrinsic sympatomimetic activity as partial agonist with less bradycardia (-b1) and slight vaso/broncho dilation (-b2) and no change in lipids (-b2) tx. angina, HTN, post-MI adv. some sedation
43
Prazosin
Alpha 1 selective receptor antagonist * decrease arteriolar, venous, sphincter resistance TX. **HTN, BPH (**decrease urinary frequency and nocturia) [**good effect on lipid profil]** ADV reflex tachycardia, **first dose effect,** **orthostatic** hypotension, urinary incontenence.
43
propranolol
**non selective** beta receptor antagonists. and **Class II antiarrhythmic** fast Na+ blocker. TX. prohylaxis post-MI, supraventricular tachyarrhythmias, **HTN** tx. angina, HT, post-MI, class II antiarrhythmic, migraine, thyrotoxicosis, performance anxiety, essential tremor adv. ++sedative and blood lipids (-b2), increases LDL and TGs, sexual dysfunction, cardiovascular depression. Caution in asthma, vasospastic disorders, diabetics (decreases insulin secretion)
45
Reserpine
reduce NE levels in the prejunctional terminal by inhibiting granule reuptake
46
Ritodrine
Beta 2 agonist Tx premature labour (relax uterus)
47
Salmeterol
Beta 2 agonist Tx asthma
48
sotalol
combined K+ channel and beta blocker
49
Sympathetic autonomic Muscarinic Ach
Sweat glands, piloerector muscles
50
tamsulosin
Alpha 1 selective receptor antagonist
51
terazosin
Alpha 1 selective receptor antagonist * decrease arteriolar, venous, sphincter resistance TX. **HTN, BPH** (decrease urinary frequency and nocturia) **[good effect on lipid profil]** ADV reflex tachycardia, **first dose** effect, **orthostatic** hypotension, urinary incontenence.
52
Terbutaline
Beta 2 agonist Tx asthma
53
timolol
non selective beta receptor antagonists adv. +sedative and blood lipids (-b2) tx. angina, HT, post-MI, open angle glaucoma
54
Tricyclic antidepressants
indirect acting adrenergic receptor agonists reuptake inhibitor NE (in part) (neurojunction)
55
Tyramine
indirect acting adrenergic receptor agonists (red wine, cheese) releaser displace NE from mobile pool (neurojunction) oral bioavail limited by MAO in GI (MAO inhibitors can lead to hypertensive crisis)
56
yohimbine
Alpha 2 selective receptor antagonist tx. postural hypotension and impotence

Pharmacology (18 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions