ANS Con't - Sympathetic (Adrenergic) Flashcards

Question

E has higher affinity for...

Answer 1

B receptor (in cardiac muscle) - increase HR & contractility - less effect on mean arterial pressure

Answer 2

- GI smooth muscle --> relaxation (B2) - GI sphincter --> contraction (a1) (used for drugs that'll cause nasal drip inhibition & decrease BP)

Answer 3

- GI smooth muscle --> contraction (M3) - GI sphinter --> relaxation

Answer 4

(When: heart failure, hypovolemia, hemorrhage, postural changes) 1. decrease BP 2. carotid sinus/aortic arch decrease firing rate of afferents 3. cardiovascular centre 4. increase symp. nerve activity & decrease parasymp nerve activity 5. increase HR, increase SV, arteriolar constriction 6. return BP back towards normal

Answer 5

if give a drug that decrease BP, it'll cause rxn of heart to increase HR to try to return to normal of if you give a drug that decrease HR SV, you'll cause arteriole constriction b/c its trying to return BP back & therefore give lower amounts & then ramp it up b/c have to consider rxn of other system

Answer 6

Destruction of sympathetic or parasympathetic nerves – Decrease function – Chemical adaptation of organ, hence, increase intrinsic tone Increase response to external neurotransmitter of organs denervated – Up regulation of cholinergic and adrenergic receptors in end organs

Answer 7

There are at least 4 types: a1, a2, b1 & b2 – Effector organs: cardiac muscle, smooth muscle and glands – All respond to both Norepinephrine (NE) and Epinephrine (E) •NE: a>b •E: b>a

Answer 8

– Vasoconstriction (medical: nasal decongestant, increase BP (trauma, shock), – Pupil dilation (Medical: eye exams) – Inhibits uterine contraction in pregnancy (Medical: Delay birth, side effect) – Ejaculation (Medical: None yet- drugs in development) – Contraction of bladder neck and prostate (Medical: Negative side effect)

Answer 9

– Located in presynaptic junction – Inhibits NT release, thus inhibiting sympathetic (adrenergic) activation (inhibits its own system/NT release; only on certain system (so won't act. everywhere) - used for changes in BP, & changes in bladder & prostate activity - act. of a2 will inhibit

Answer 10

Though it inhibits adrenergic activation, its not complete nor perfectly opposite of 1

Answer 11

– Kidney • Renin release causes vasoconstriction – Heart: • Increases – Heart rate (tachycardia) – Force of contraction (increase workload of heart to increase BF) – Velocity of conduction in AV node (ability of heart to beat faster)

Answer 12

Beta2 (lungs, metabolism & uterinary contraction) – Bronchial dilation – Relaxation of uterine muscle – Vasodilation – Glycogenolysis – Glucagon release (increase glucose into blood) • Dopamine – Dilates renal blood vessels *

Answer 13

B2 - but if you're given a drug that activates B2, it's gonna activate B1 & a1, so you'll get increase BP, increase HR (therefore not specific but we can use an inhaler)

Answer 14

Increases vasoconstriction, pupil dilation, relaxes uterine contraction, contraction of bladder and prostate neck, ejaculation (increase BP)

Answer 15

Cardiac vasoconstriction, Inhibits NE brain release, Inhibits insulin release

Answer 16

Increases HR and contraction, Renin release

Answer 17

Lung bronchi dilation, relax uterus, vasodilation, Glucose release

Answer 18

IP3, DAG blood vessels, GI sphincter agonist: pseudophedrine (taken to dry your nose) antagonist: prazosin (inhibits a1 (good to decrease BP or contraction of bladder neck)

Answer 19

decrease cAMP presynaptic terminal agonist: clonidine (act. a2 which inhib a1, which lower BP)

Answer 20

increase cAMP heart (to make it beat harder) agonist: isoproterenol, dobutamine - act B1, which increase HR & SV (caffeine, nic, etc. any stimulates do this as well) antagonist: propanolol - decrease heart activity

Answer 21

increase cAMP airway, GI urogenital agonist: isoproterenol, terbutaline - act. B2, help lungs, increase cAMP antagonist: propanolol - inibit B2