ANS Pharmacology Flashcards

1
Q

prazosin, terazosin, doxazosin target

role

A
  • alpha 1

- antagonist

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2
Q

sympathetic function

A
  • stimulates smooth muscle contraction
  • stimulates smooth muscle relaxation
  • stimulates SA/AV node depolarization
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3
Q

M3 receptor role

A
  • secretion- smooth muscle contraction
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4
Q

vascular contraction and dilation are regulated normally by which parasympathetic receptors

A
  • none!
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5
Q

problems with parasympathetic drugs

A
  • toxicities may be a problem
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6
Q

beta 1 antagonist role

A
  • decreased cardiac output
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7
Q

sympathetic hormones

A
  • epineprhine- norepinephrine
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8
Q

alpha 2 role

A
  • smooth muscle contraction
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9
Q

alpha 1 receptor role

A
  • smooth muscle contraction
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10
Q

M2 antagonist role

A
  • increased cardiac output
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11
Q

route of administration of parasympathetic drugs

A
  • route of admin is key
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12
Q

beta 1 role

A
  • SA/AV node depolarization
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13
Q

M2 receptor role

A
  • inhibits SA/AV node depolarization
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14
Q

dobutamine target

role

A
  • beta 1

- agonist

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15
Q

parasympathetic hormones

A
  • acetylcholine
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16
Q

beta 2 agonist vascular drugs

A
  • none
17
Q

M2 agonist drug

A
  • none
18
Q

acetylcholine receptors

A
  • M2 and M3
19
Q

M2 antagonist drugs

A
  • atropine- glycopyrrolate
20
Q

beta 1 antagonist drugs

A
  • metoprolol

- atenolol

21
Q

phenylephrine target

role

A
  • alpha 1

- agonist

22
Q

beta 1 agonist roles

A
  • SA/AV node depolarization
  • increased HR
  • increased cardiac output
23
Q

beta 1 agonist drugs

A
  • dobutamine

- isoproterenol

24
Q

sympathetic receptors

A
  • alpha 1 and 2

- beta 1 and 2

25
Q

dominant sympathetic receptor on the heart

role

A
  • beta 1

- increase HR

26
Q

selectivity of parasympathetic drugs

A
  • nonselective for M1-M5
27
Q

beta 2 antagonist vascular drugs

A
  • none
28
Q

parasympathetic function

A
  • stimulates secretion from glands
  • stimulates smooth muscle contraction
  • inhibits SA/AV node depolarization
29
Q

beta 2 role

A
  • smooth muscle relaxation
30
Q

vascular contraction and dilation are regulated normally by which sympathetic receptors

which causewhich one wins?

A
  • alpha 1 - vasoconstriction - increase BP
  • beta 2 - vasodilation - decrease BP
  • more alpha 1 than beta 2 so alpha 1 wins
31
Q

dominant parasympathetic receptor on the heart

role

A
  • M2

- decrease HR

32
Q

isoproterenol target

role

A
  • beta 1, 2, 3

- agonist

33
Q

epinephrine target

role

A
  • alpha 1,2
  • beta 1,2
  • agonist
34
Q

norepinephrine target

role

A
  • alpha 1,2
  • beta 1,3
  • agonist
35
Q

autonomic functions in all organ systems

A
  • secretion
  • smooth muscle contraction
  • smooth muscle relaxation -
    AV/SA node changes in cardiac myocyte
36
Q

M2 agonist role

A
  • SA/AV node hyperpolarization
  • decreased HR
  • reduced cardiac output
37
Q

selectivity of sympathetic drugs

A
  • selective for single receptors or a subset of receptors
38
Q

alpha 1 antagonists vascular drugs

A
  • prazosin- terazosin- doxazosin
39
Q

clonidine target

role

A
  • alpha 2 presynaptic

- agonist