ANS Pharmacology Flashcards
(39 cards)
1
Q
prazosin, terazosin, doxazosin target
role
A
- alpha 1
- antagonist
2
Q
sympathetic function
A
- stimulates smooth muscle contraction
- stimulates smooth muscle relaxation
- stimulates SA/AV node depolarization
3
Q
M3 receptor role
A
- secretion- smooth muscle contraction
4
Q
vascular contraction and dilation are regulated normally by which parasympathetic receptors
A
- none!
5
Q
problems with parasympathetic drugs
A
- toxicities may be a problem
6
Q
beta 1 antagonist role
A
- decreased cardiac output
7
Q
sympathetic hormones
A
- epineprhine- norepinephrine
8
Q
alpha 2 role
A
- smooth muscle contraction
9
Q
alpha 1 receptor role
A
- smooth muscle contraction
10
Q
M2 antagonist role
A
- increased cardiac output
11
Q
route of administration of parasympathetic drugs
A
- route of admin is key
12
Q
beta 1 role
A
- SA/AV node depolarization
13
Q
M2 receptor role
A
- inhibits SA/AV node depolarization
14
Q
dobutamine target
role
A
- beta 1
- agonist
15
Q
parasympathetic hormones
A
- acetylcholine
16
Q
beta 2 agonist vascular drugs
A
- none
17
Q
M2 agonist drug
A
- none
18
Q
acetylcholine receptors
A
- M2 and M3
19
Q
M2 antagonist drugs
A
- atropine- glycopyrrolate
20
Q
beta 1 antagonist drugs
A
- metoprolol
- atenolol
21
Q
phenylephrine target
role
A
- alpha 1
- agonist
22
Q
beta 1 agonist roles
A
- SA/AV node depolarization
- increased HR
- increased cardiac output
23
Q
beta 1 agonist drugs
A
- dobutamine
- isoproterenol
24
Q
sympathetic receptors
A
- alpha 1 and 2
- beta 1 and 2
25
dominant sympathetic receptor on the heart
role
- beta 1
| - increase HR
26
selectivity of parasympathetic drugs
- nonselective for M1-M5
27
beta 2 antagonist vascular drugs
- none
28
parasympathetic function
- stimulates secretion from glands
- stimulates smooth muscle contraction
- inhibits SA/AV node depolarization
29
beta 2 role
- smooth muscle relaxation
30
vascular contraction and dilation are regulated normally by which sympathetic receptors
which causewhich one wins?
- alpha 1 - vasoconstriction - increase BP
- beta 2 - vasodilation - decrease BP
- more alpha 1 than beta 2 so alpha 1 wins
31
dominant parasympathetic receptor on the heart
role
- M2
| - decrease HR
32
isoproterenol target
role
- beta 1, 2, 3
| - agonist
33
epinephrine target
role
- alpha 1,2
- beta 1,2
- agonist
34
norepinephrine target
role
- alpha 1,2
- beta 1,3
- agonist
35
autonomic functions in all organ systems
- secretion
- smooth muscle contraction
- smooth muscle relaxation -
AV/SA node changes in cardiac myocyte
36
M2 agonist role
- SA/AV node hyperpolarization
- decreased HR
- reduced cardiac output
37
selectivity of sympathetic drugs
- selective for single receptors or a subset of receptors
38
alpha 1 antagonists vascular drugs
- prazosin- terazosin- doxazosin
39
clonidine target
role
- alpha 2 presynaptic
| - agonist
