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Cardio Pharm Quiz > Anti-Platelets/Anti-Coagulants > Flashcards

Anti-Platelets/Anti-Coagulants Flashcards

(52 cards)

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1
Q

dabigatran category of drug

A

oral direct acting thrombin inhibitor

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2
Q

drug interactions with warfarin

A
  • NSAIDS- Amiodarone- Cimetidine
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3
Q

UFH/LMWH MOA

A
  • inhibits factors Xa and thrombin by acting on anti-thrombin
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4
Q

when do we give fibrinolytic drugs?

A
  • immediately to treat STEMIS
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5
Q

enoxaparin is given how?

A
  • subQ
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6
Q

half life of factor 10a

A
  • 40 hours
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7
Q

warfarin/coumadin category of drugs

A

oral indirect acting vitamin K inhibitors

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8
Q

P2y12 inhibitors MOA

A
  • irreversibly block ADP receptor binding for platelets

- non competitive antagonists

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9
Q

MOA of warfarin

A
  • vitamin K reductase inhibitor
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10
Q

what is an alternative to heparin in patients with HIT?

A
  • argatroban
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11
Q

how do we manage until warfarin kicks in?

A
  • heparin bridging
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12
Q

argatroban category of druggiven how

A
  • direct acting thrombin inhibitor

- IV

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13
Q

COX1/2 inhibitors used to treat

A
  • unstable angina- MI- stroke
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14
Q

P2y12 inhibitors used to treat

A
  • MI - stroke
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15
Q

how must GPIIb/IIIa inhibitors be given?

A
  • IV
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16
Q

before warfarin effects begin, what must happen?

A
  • affected coagulation factors must degrade
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17
Q

diet and warfarin

A
  • variability in diet makes warfarin dosing problematic

- dependent on vitamin K intake

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18
Q

half life of factor 7a

A
  • 6 hours
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19
Q

what proteins is vitamin K responsible for

A
  • 2- 7- 9- 10- proteins C and S
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20
Q

GPIIb/IIIa inhibitors MOA

A
  • prevent activated platelets from sticking together
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21
Q

Abciximab class of drug

Study These Flashcards
A
  • GPIIb/IIIa inhibitor
22
Q

what part of heparin binds to the anti-thrombin

Study These Flashcards
A
  • the pentasaccharide
23
Q

toxicities of COX 1/2 inhibitors

Study These Flashcards
A
  • gastric damage
24
Q

when do we give Streptokinase or alteplase

Study These Flashcards
A
  • immediately to treat pulmonary emboli
25
fondaparinux MOA
- inhibits factor Xa by acting on anti-thrombin
26
half life of factor 2a (thrombin)
- 60 hours
27
UFH toxicities
- heparin-induced thrombocytopenia
28
unfractionated heparin and enoxaparin category of drug
- indirect acting thrombin and factor Xa inhibitors
29
half life of factor 9a
- 24 hours
30
role of Alteplase and Streptokinasehow must they be administered
- proteins that convert inactive plasminogen into active plasmin - IV because they are large molecules
31
fondaparinux category of druggiven how
- indirect acting factor Xa inhibitor | - SubQ
32
fibrinolytics should definitely not be used for
- strokes caused by cerebral hemorrhage | - those patients who for blood clotting is good
33
unfractionated heparin is given how?
- IV- SubQ- too large a molecular size
34
COX1/2 inhibitors MOA
- inhibit COX synthesis of TXA2
35
Pharmacokinetics issues with wafarin
- slow onset of action - may take up to a week to reach therapeutic levels - polymorphism issues - variability in diet
36
When can we also give alteplase
- immediately to treat stroke
37
aspirin class of drug
- COX1/2 inhibitor
38
how Amiodarone and Cimetidine interact with warfarin
- decrease warfarin metabolism | - increase INR
39
Tirofiban class of drug
- GPIIb/IIIa inhibitor
40
how does heparin-induced thrombocytopenia occur
- platelet coated with immune complex and heparin | - platelet removed by splenic macrophages
41
Eptifibitide class of drug
- GPIIb/IIIa inhibitor
42
how NSAIDS impact warfarin
- kick warfarin off albumin- increase free warfarin- increase bleeding risk
43
clopidogrel class of drug
- P2y12 inhibitors
44
platelet activation is what phase of hemostasis?
- primary hemostasis
45
- apixaban, rivaroxaban, edoxaban category of drug
oral direct acting factor Xa inhibitor
46
GPIIb/IIIa inhibitors used to treat
- angioplasty- stent placement
47
what is fondaparinux really?
- only the pentasaccharide portion of heparin
48
Warfarin toxicities
- birth defects- fetal warfarin syndrome- category X toxin
49
thrombin activation is what phase of hemostasis?
- secondary hemostasis
50
Pharmacokinetics issues with P2y12 inhibitors
- given in the prodrug form first - must be activated by CYP2C19- slow metabolizers (activators) will have reduced therapeutic effects
51
role of TXA2
- platelet activation and aggregation
52
which polymorphisms affect warfarin dosing?
- VKORC1- CYP2C9

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