Anti Arrhythmias

Question 1

All class I

Answer 1

Block Na+ channels

Widen QRS

Question 2

Procainamide blocks Na+ & K+ channels what will you predict the drug to do

Answer 2

Widen QRS &

Prolong QT wate

Question 3

Quinidine is a Na+ channel blocker, K+ channel blocker, muscarinic antagonist

Answer 3

It will widen QRS, prolong QT wave, increase HR/shorten PR interval

Question 4

Disopyramide is a Na+, K+ blocker, and antimuscarinic

Answer 4

Widen QRS, prolong QT, decrease PR interval/increase HR

Question 5

Lidocaine and mexiletine block Na+ channels only, what are the effects

Answer 5

Widen QRS

Question 6

Flecainide is a Na+ blocker and blocks K+ and Ca+? What are the effects

Answer 6

Widen QRS
Prolong QT
Prolong PR/ decrease HR

Question 7

Propafenone blocks Na+ and is an Beta Adrenergic antagonist. What are the effects?

Answer 7

Widen QRS

Prolong PR interval = decrease HR

Question 8

Dronedarone is like amiodarone but doesnt look like TH

Answer 8

It has less side effects but does not work as well

Question 9

Dofetilide & Ibutilide are pure K+ channel blockers. What are the effects?

Answer 9

Prolong QT interval

Only used in hospitals because it causes torsades de pointes (FATAL)

Question 10

How to know all the classes?

Answer 10

Some block potassium channels

Question 11

Class IV are CCBS but only include the ones who affect the heart which drugs are they? What are their effect?

Answer 11

Verapamil & diltiazem

Prolong PR interval = decrease HR

Question 12

Magnesium has an unknown MOA but is used to

Answer 12

Torsades de points

Question 13

Sotalol select 4

Answer 13

Is a beta blocker
Is a K+ blocker

Prolongs PR
Prolongs QT

Question 14

Person with history of fibrillation and has halos and glare in both eyes. What antiarrhyt are they taking?

Answer 14

Amiodarone

Question 15

Amiodarone

Class
MOA
EFFECTS
ADRS

Answer 15

• CLASS III: K+ channel blockers
  TH, blocks Na+, K+ & ca+
  Adrenergic alpha and beta
• widens QRS, prolongs QT, prolongs PR
• corneal micro deposits, blurred vision, halos, pulmonary fibrosis

Question 16

Sotalol

Class
MOA
Effect

Answer 16

Class III: K+ channel blocker

• blocks K+ & non selective beta blocker
• increased QT , prolong PR

Question 17

Verapamil/ diltiazem

Class
MOA
SOA
Effect

Answer 17

Class IV
Block ca+
SOA: slow responding tissue
Prolong PR/ decrease HR

Question 18

Digoxin
MOA
Effects

Answer 18

+inotropic agent = increases contractile force
-prominent vagotonic action: increases Ach and slows AV conduction

Effect: increases PR

Question 19

Atropine

MOA
Effect
ADRs

Answer 19

Non selective muscarinic antagonist (M1,M2,M3)

Block vagal activity to speed AV conduction & increase HR

Anti dumbells
Mydriasis
CI w. Angle closure glaucoma

Question 20

Drugs that affects SA & AV node?

Answer 20

Beta blockers, CCBs, M2 agonist/antagonist

Question 21

Effects of blocking Na+?

Answer 21

Alters TH for excitability
Reduces phase 0 slope

WIDEN QRS

Question 22

Effects of blocking K+?

Answer 22

Takes longer to repolarize

PROLONG QT

Question 23

Effects of blocking Ca+?

Answer 23

Prolongs PR/ decreases HR

Question 24

Effects of muscarinic antagonist ?

Answer 24

Shortens PR interval = increases HR

Question 25

Effects of BB?

Answer 25

Prolong PR= decreases HR

Question 26

Which drug is able to prolong PR & QT, widen QRS, and increase threshold?

Answer 26

Amiodarone

Question 27

Digoxin increases

Answer 27

Contractile force

Question 28

May cause yellow vision or halos

Answer 28

Digoxin

Question 29

Which of the following may increase the risk for corneal micro deposits

Answer 29

Amiodarone