HTN Drugs

Question 1

ALISKIREN is a

Answer 1

Renin enzyme antagonist

Question 2

What 3 effects can an ACEi produce?

Answer 2

1. Inhibit conversion of AngI to AngII
2. Increase Ang 1-7 levels
3. Increase levels of bradykinin (VD)

Question 3

Which RAAS drug is more likely to decrease angiotensin II plasma levels?

Answer 3

Lisinopril

Question 4

Valsartan decreases pressure by?

Answer 4

Blocking the activation of the A1 receptor

Question 5

If pt is on losartan/aliskiren & you give them clycosporine, grapefruit juice, itraconazole,(CYP3A4 inhibitors) what will happen?

Answer 5

Enzyme will metabolize less-> increasing concentration in plasma -> toxic

Question 6

Pt is taking aliskiren, and was prescribed fluconazole (CPY3A4 inhibitor) . What will happen to the aliskiren plasma level?

Answer 6

Aliskiren plasma level will increase

Question 7

Which drugs decreases TPR by selective inhibition of the AT1 receptor?

Answer 7

Losartan

Question 8

Valsartan may cause which of the following?

• hypotension
• hyperkalemia
• fetus damage
• increase in serum creatine
• All of the above

Answer 8

All of the above

Question 9

Which of the following is incorrect about Candesartan?

• decreases after load
• decreases pre load
• decreases AT1 activation
• decreases plasma levels of ANGII

Answer 9

Decreases ANG II

Question 10

Neighbor took double doe of furosemide. Which ADR is more likely?

Answer 10

Dehydration

Question 11

Side effect of taking propranolol?

Answer 11

Bradycardia

Question 12

Decreases afterload by blocking L-type Ca++ channels

Answer 12

Nifedipine