Anti-arrhythmias

Question 1

Isoprotenolol

Answer 1

β1 stimulated increase in HR

Question 2

Class IV MOA

Answer 2

CCB; Similar to class II. Nodal depression of automaticity. Also reduce ventricular contractility

Question 3

Encainide

Answer 3

Class Ic

Question 4

Flecainide

Answer 4

Class Ic

Question 5

Phenytoin

Answer 5

Class Ib

Question 6

Class Ic MOA

Answer 6

Strong binding to sodium channel. No effect on AP and strong effect on depolarization

Question 7

Class Ia Therapeutic Use

Answer 7

PAT PSVT Long QT VT

Question 8

Class II Therapeutic Use

Answer 8

SVT (PAT) Nodal dysrhythmia Digoxin-induced Maintenance

Question 9

Metoprolol

Answer 9

Class II

Question 10

Tocainide

Answer 10

Class Ib

Question 11

Diltiazem

Answer 11

Class IV

Question 12

Class III Therapeutic Use

Answer 12

Refractory dysrhythmia Prolonged plateau

Question 13

Class Ib Therapeutic Use

Answer 13

Post-MI or digoxin-induced tachycardia

Question 14

Class Ia Therapeutic Use

Answer 14

PAT PSVT Long QT VT

Question 15

Atenolol

Answer 15

Class II

Question 16

Adenosine

Answer 16

Convert reentrant SVT (PVT, PSVT, WPW) AV hyperpolarization Complete AV nodal block that degrades in seconds

Question 17

Class IV Therapeutic Use

Answer 17

SVT; rapid conversion

Question 18

Class Ia MOA

Answer 18

Moderate binding to sodium channels. Prolong AP and have moderate effect on phase 0

Question 19

Ibutilide

Answer 19

Class III

Question 20

Verapamil

Answer 20

Class IV

Question 21

Disopyramide

Answer 21

Class Ia

Question 22

Esmolol

Answer 22

Class II

Question 23

Class I MOA (General)

Answer 23

Na+ channel blocker (Conducting system)

Question 24

Digoxin

Answer 24

Class V (IId?)

Question 25

Class III MOA

Answer 25

Multiplicity of membrane effects at K+, Ca+2, Na+ as well as β-receptors. Prolong phase 3 (plateau)

Question 26

Adenosine

Answer 26

Class V (IIe?)

Question 27

Amiodarone

Answer 27

Class III

Question 28

Sotalol

Answer 28

Class III- Note D/L variant

Question 29

Digoxin

Answer 29

Chronic a. fib treatment. CCBs are preferred due to dig. low therapeutic index.

Question 30

Class Ic Therapeutic Use

Answer 30

Refractory or life threatening ventricular dysrhythmia

Question 31

Propafenone

Answer 31

Class Ic

Question 32

Propranolol

Answer 32

Class II

Question 33

Lidocaine

Answer 33

Class Ib

Question 34

Moricizine

Answer 34

Class Ic

Question 35

Class II MOA

Answer 35

β-blocker; reduce effect of sympathetic stimulation. Nodal depression of automaticity & ventricular contractility

Question 36

Quinidine

Answer 36

Class Ia

Question 37

Class Ib MOA

Answer 37

Weak binding to sodium channel. Shorten AP and have week effect on phase 0.

Question 38

Atropine

Answer 38

Produces vagal block, increasing heart rate

Question 39

Procainamide

Answer 39

Class Ia

Question 40

Mexiletine

Answer 40

Class Ib

Question 41

Bretylium

Answer 41

Class III