Sympathomimetics Flashcards
(47 cards)
Methoxyamine
alpha-1 agonist
Alpha-1 agonist MOA
Increases vasoconstriction peripherally
Increases pressures
May not impact CO
Alpha-1 Agonist Clinical Use
Hypotension
Shock
Alpha-2 Agonist MOA
Increases vasoconstriction if used locally
Decreases NE release systemically (Reduce sympathetic outflow)
Alpha-2 Agonist Clinical Use
Treat hypertension (esp. in pregnancy)
Alpha-methyldopa
Alpha-2 agonist
Beta-1 Agonist MOA
Increases sympathetic outflow
Increased CO
Increased renin production
Beta-1 Agonist Clinical Use
Treatment of heart failure and cardiogenic shock
Increase CO
Dobutamine
Beta-1 Agonist
Beta-2 Agonist MOA
Increases sympathetic outflow
Bronchodilation
Beta-2 Agonist Clinical Use
Asthma
COPD
Obstructive Lung Disease
Metaproterenol
Beta-2 Selective Agonist
Albuterol
Beta-2 Selective Agonist
Terbutaline
Beta-2 Selective Agonist
Salmeterol
Beta-2 Selective Agonist
Formoterol
Beta-2 Selective Agonist
Isoproterenol
Non-selective Beta Agonist
Epinephrine
Catecholamine
a1=a2; b1=b2
Epinephrine Uses
Asthma (b2)
Anaphylaxis (b2, b1, a1)
Norepinephrine
Catecholamine
a1=a2; b1»>b2
Norepinephrine Uses
Cardiogenic shock
Dopamine
Catecholamine
D»>b»>a
Dopamine Uses
Shock 2/2 low CO or renal failure
Propranolol
Non-selective beta antagonist