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Pharm 225A > Anti-Arrhythmic > Flashcards

Anti-Arrhythmic Flashcards

1
Q

Quinidine Class/MoA

A
  • class 1A
  • blocks Na+ –> slow conduction velocity, prolonged refraction
  • highly protein bound
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2
Q

Quinidine D-D interactions

A
  • 2D6 inhibitor drugs (digoxin, warfarin, BBs)
  • QT prolonging drugs such as digoxin
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3
Q

Quinidine AEs

A
  • diarrhea
  • lightheadedness
  • thrombocytopenia, hepatitis, QT-prolongation
  • torsades, Vtach
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4
Q

Procainamide class/MoA

A
  • class 1A
  • blocks Na+ –> slow conduction velocity, prolonged refraction
  • IV, activated in liver
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5
Q

Procainamide drug interactions

A
  • CYP2D6 substrate
  • QT prolonging drugs
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6
Q

Procainamide AEs

A
  • hypotension
  • torsades de pointes
  • nausea
  • coagulation disorders
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7
Q

Disopyramide class and MoA

A
  • class 1A
  • sodium blockade –> slow conduction velocity, prolonged refraction
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8
Q

Disopyramide drug interactions & AEs

A
  • QT-prolonging drugs
  • AEs: decreases contractility, xerostomia, constipation, urinary hesitancy
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9
Q

Lidocaine class/MoA

A
  • class 1B
  • accelerates repolarization
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10
Q

Lidocaine uses

A
  • treats ventricular arrhythmias associated with MI
  • local anesthesia
    chronic pain
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11
Q

Lidocaine AEs

A
  • dizziness, drowsiness, N/V, blurred vision, hallucinations
  • seizures, bradycardia, respiratory depression
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12
Q

Flecanide class/MoA

A
  • Class 1C
  • blocks Na+
  • profoundly slows conduction velocity without altering refraction
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13
Q

Flecanide AEs/interactions

A
  • AEs: dizziness, blurred vision, dyspnea, pro-arrhythmia, HF exacerbation
  • interacts w/ CYP2D6 substrate
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14
Q

Propafenone class/MoA

A
  • class 1C
  • sodium blockade
  • profoundly slows conduction velocity without altering refraction
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15
Q

Propafenone AEs

A
  • new or worsening arrhythmia, VTach, bradycardia, HF exacerbation, CNS effects
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16
Q

Propafenone D-D interactions

A
  • avoid with other anti arrhythmics and QT prolonging drugs
  • CYP2D6 substrate/inhibitor (digoxin, warfarin, BB, etc)
17
Q

Amiodarone class/MoA

A
  • class III agent
  • K, Ca, Na blockades
  • slowed HR, AV conduction, QT prolongation
18
Q

Amiodarone Uses

A
  • treats/prevents V-Fib and V-Tach
  • prevention of atrial tachycardia
19
Q

Amiodarone AEs

A
  • optic neuritis
  • photosensitivity, blue slate skin discoloration
  • hypothyroidism, GI issues
  • corneal micro deposits
20
Q

Amiodarone BBWs

A
  • pt should be in hospital when initiating
  • pro-arrhythmic (bradycardia)
  • hypotension
21
Q

monitor when using amiodarone

A
  • Liver function tests
  • thyroid function tests
  • pulmonary function tests
22
Q

Ibutilide class/MoA

A
  • Class III
  • K, Ca, and Na channel blockade –> slowed HR/AV conduction; QT prolongation
23
Q

Ibutilide AEs/D-D interactions

A
  • AEs: arrhythmias, hypotension (monitor EKG for at least 4 hrs after admin)
  • do not use with other QT prolonging drugs
24
Q

Sotalol class/MoA

A
  • class III
  • K, Ca, and Na channel blockade –> slowed HR/AV conduction; QT prolongation
  • non selective BB
25
Q

Sotalol AEs/D-D interactions

A
  • AEs: bradycardia, hypotension, QT prolongation
  • do not use with other QT prolonging drugs or those that decrease HR
26
Q

Dofetilide Class and MoA

A
  • class III
  • K, Ca, and Na channel blockade –> slowed HR/AV
27
Q

Dofetilide AEs/D-D interactions

A
  • AEs: torsades and other arrhythmias
  • do not use with other QT prolonging drugs
28
Q

Drugs for rate control in atrial fibrillation

A
  • Beta blockers
  • Ca channel blockers
  • Digoxin (must be in combo w/ another drug)
29
Q

Drugs for rhythm control in atrial fibrillation

A

Class 1C: flecainide & propafenone
Class III: amiodarone, dofetilide, ibutilide

30
Q

Drugs for ventricular arrhythmias

A
  • Lidocaine
  • Procainamide
  • Amiodarone

Pharm 225A (7 decks)

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